班布特罗的合成  

The Synthesis of Ba m buterol

作　　者：苏国强[1] 侯建英[1] 朱崇泉[1] 边军[1] 冷宗康[1] 

机构地区：[1]江苏省药物研究所,南京210009

出　　处：《中国药科大学学报》1999年第4期251-252,共2页Journal of China Pharmaceutical University

摘　　要：班布特罗作为支气管解痉药具有作用时效长，副作用特别是对心血管系统的副作用非常微弱等优点。作者对文献合成方法进行了合理的改进，避免使用苄基保护的特丁胺和加压氢化还原脱苄基，简化了实验步骤和原材料，反应总收率比文献收率提高了１ ．５ 倍，达到５６ ％ ，较大地降低了生产成本。Bambuterol ,as a bronchodilator ,exhibits the prolonged duration of bronchospasmolytic activity and verylow side effects especially to heart blood vessal system . The synthetic method of bambuterol was improved , inimproved method the compound of t butylamine was used directly so as to avoid hydrogenation debenzyl protectedgroup at pressure ,and the procedures and the start material were more sutible to the industrial manufactural scale inour country because the total yield 56 % was one and half times higher than that of reported .

关 键 词：班布特罗 合成 抗哮喘药 

分 类 号：TQ463[化学工程—制药化工] R924.3[医药卫生—药学]