压力对心腔内造影剂微气泡后向散射强度的影响  

Effects of Pressure on Intracardiac Backscatter from Microbubbles

作　　者：邓又斌[1,2] 松本正幸[1,2] 潼泽哲 黎春蕾[1,2] 张友耿 

机构地区：[1]武汉同济医科大学附属同济医院超声诊断科 [2]日本金泽医科大学

出　　处：《中国超声医学杂志》1999年第8期567-569,共3页Chinese Journal of Ultrasound in Medicine

摘　　要：目的与方法：本研究应用声学密度法在体外搏动心脏模型中定量分析压力对声振白蛋白微气泡后向散射强度的影响，并观察正常人体心腔内双氧水微气泡后向散射强度在心动周期中的变化规律。结果：Ａｌｂｕｎｅｘ声振白蛋白微气泡在心腔内压力的作用下，其大小可发生可逆性变化，而这种变化可相应地引起后向散射强度可逆的周期性变化。舒张末期和收缩末期后向散射强度之差与造影剂浓度无关，而与收缩末期压力高低密切相关。在初步的人体研究中，我们也观察到了同样的心腔内造影剂后向散射强度的变化规律。结论：有可能通过应用声学密度法观察心腔内造影剂微气泡后向散射强度变化、无创性估计心腔内压力。Objective and Methods: The backscatter from sonicated albumin microbubbles(Albunex)was analyzed using acoustic densitometry in an in vitro pulsatile heart model to evaluate the effects of pressure on the backscatter from Albunex,and the cardiac cyclic changes of intracardiac backscatter from hydrogen peroxide microbubbles in 14 healthy persons were analyzed. Results: It was found that the Albunex microbubbles were compressed in systole and decompressed in diastole,causing corresponding changes of backscatter in cardiac cycle.Although the intensities of backscatter in diastole and systole were related with the concentration of microbubbles,the concentraton of microbubbles had no effects on the difference of enddiastolic and endsystolic backscatter.The difference of the backscatter was highly correlated with endsystolic pressure(r=096,P=0001).In human studies,we also observed same intracardiac cyclic changes of backscatter from hydrogen peroxide microbubbles. Conclusion: Our study indicates that it is possible to evaluate the intracardiac pressure noninvasively by analyzing the intracardiac backscatter from the microbubbles with acoustic densitometry.

关 键 词：超声后向散射 造影剂微气泡 心腔内压力 

分 类 号：R445.1[医药卫生—影像医学与核医学] R981[医药卫生—诊断学]