急性冠脉综合征患者血尿酸升高相关因素分析  

Analysis of factors associated with the hyperuricemia occurrence in acute coronary syndrome patients

作　　者：刘军翔[1,2] 张华[2] 王麒[2] 汤庆林[2] 孙睿轩[2] 张桂芬[2] 周学兵[2] 张明华[2] 周欣[2] 庞博[2] 

机构地区：[1]天津医科大学研究生院,天津300070 [2]天津武警医学院附属医院

出　　处：《山东医药》2011年第11期37-38,共2页Shandong Medical Journal

摘　　要：目的探讨急性冠脉综合征(ACS)患者血尿酸升高的相关危险因素。方法将228例ACS患者按照血尿酸水平分为A组(血尿酸<260.0μmol/L)、B组(血尿酸260.0～305.5μmol/L)、C组(血尿酸305.5～376.5μmol/L)、D组(血尿酸>376.5μmol/L)组,观察各组性别、年龄、高血压史、糖尿病史、吸烟史、左心室的射血分数(LVEF)、血尿素氮(BUN)、血肌酐(Cr)、总胆固醇(CHO)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、空腹血糖(BFS),采用Logistic回归分析血尿酸升高的主要因素。结果四组间性别、吸烟史、BUN、Cr、TG和LVEF存在统计学差异,P<0.05;Logistic回归分析显示,BUN、Cr、TG、吸烟史是ACS患者血尿酸升高的危险因素。结论 BUN、Cr、TG水平升高和吸烟可能为ACS患者发生高尿酸血症的重要原因。Objective To investigate the risk factors associated with the hyperuricemia occurrence in acute coronary syndrome patients.Methods Two hundered and twenty-eight patients with acute coronary syndrome were divided into Group A（UA260.0 μmol/L）,Group B（UA〈 260.0-305.5 μmol/L）,Group C（UA 305.5-376.5 μmol/L）,Group D（UA〉376.5 μmol/L） according to plasma uric acid levels.The biochemistry data（gender,age,history of hypertension,history of diabetes,smoking history,LVEF,BUN,Cr,TC,TG,HDL,LDL,BFS）of the patients were collected,and their relationships with hyperuricemia were analyzed with multivariate logistic regression models.Results Among four groups,there were significant differences of sex,smoking history,BUN,Cr and TG,P〈0.05.Multivariate analysis showed that smoking history,BUN,Cr and TG were significantly associated with hyperuricemia occurrence in acute coronary syndrome patients.Conclusions The high level of BUN,Cr,TG and smoking may have significant effects to hyperuricemia occurrence in acute coronary syndrome patients.

关 键 词：急性冠脉综合征 尿酸 危险因素 

分 类 号：R541.4[医药卫生—心血管疾病]