应用超声微泡对正常和不同程度缺血心肌微循环血流速度及血流状态的研究  

Ultrasound Microbubbles for Measuring Blood Flow Velocity and Observing Blood Flow Status of Normal and Ischemic Myocardium Microcirculation

作　　者：孙幼屏[1] 郑元义[1] 李攀[1] 周文格[1] 凌智瑜[1] 王志刚[1] 

机构地区：[1]重庆医科大学附属第二医院超声科,重庆医科大学超声影像学研究所,重庆市400010

出　　处：《中国超声医学杂志》2011年第3期197-199,共3页Chinese Journal of Ultrasound in Medicine

基　　金：国家自然科学基金面上项目(No.30770565),国家自然科学基金面上项目(No.30770566)

摘　　要：目的通过单个超声微泡研究正常及小同缺血程度下的心肌微循环血流速度及血流状态。方法采用1 5只实验犬用"DFY型超声图像定量分析仪"观测心肌正常微循环的血流速度。建立不同程度冠脉狭窄的心肌缺血模型,并观测缺血心肌的血流状态及速度。结果正常心肌微循环的血流速度为(6.25±1.27)mm/s,心肌50%、90%和100%缺血时心肌微循环的血流速度分别为(2.3±0.57)mm/s、(0.1±0.04)mm/s和(0.05±0.01)mm/s。随冠脉狭窄程度加大血流速度明显减慢(P<0.05)。结论本实验所用方法是一种无创、动态实时、直接测量心肌微循环血流速度的新技术。Objective The study aims to investigate blood flow velocity and blood flow status of microcirculation in normal myocardium, ischemic myocardium by using ultrasound microbubbles. Methods Blood flow velocity of normal mierocirculation in myocardium was determined, using DFY- Ⅱ Ultrasound Imaging Analysis Software among 15 experimental dogs. Dog models of myocardial ischemia with coronary stenoses of different degrees were established blood flow status in ischemic myocardium was observed, and blood flow velocity was measured. Results The blood flow velocities in normal myoeardium was 6.25±1.27 mm/s. In dogs with 50%, 90%, and 100% myocardial ische- mia, the myocardial blood flow velocities were 2.3±0.57 mm/s,0.1±0.04 mm/s, and 0.05±0.01 mm/s, respectively. Blood flow gradually slowed down as the artificial stenosis aggravated （P〈0.05）. Conclusions A noninvasive, dynamic real time, simple, and direct method to determine microcirculation blood flow velocity in deep organs is suecessfully established.

关 键 词：超声微泡 缺血心肌 微循环 血流速度 

分 类 号：R445.1[医药卫生—影像医学与核医学]