人体对砖茶中氟和铝的吸收与排泄作用观察  

Absorption and excretion of fluoride and aluminum after drinking brick tea in healthy adults

作　　者：刘庆斌 李海蓉[2] 王玉华 王五一[2] 刘晓波 王革 田淑彩 英殿双 于冰 王丽珍[2] 冯福建[2] 

机构地区：[1]内蒙古呼伦贝尔市地方病防治研究所,162650 [2]中国科学院地理科学与资源研究所环境地理与人类健康研究室

出　　处：《中国地方病学杂志》2011年第2期134-136,共3页Chinese Jouranl of Endemiology

基　　金：国家自然科学基金（40471008）;内蒙古自治区自然科学基金（20050800920）

摘　　要：目的观察砖茶中的氟、铝在人体内吸收、排泄和贮留的基本情况。方法选择地方性氟中毒非病区的10名健康人作为观察对象，男、女各半，饮用砖茶（含氟量5．97mg／L，含铝量7．53mg／L）。采用氟离子选择电极法和时序式电感耦合等离子体发射光谱法（ICP—AES）检测饮用砖茶前空腹与饮用砖茶后1．0、2．0、4．0、〉4．0-〈24．0h及24．0h后空腹尿含氟、铝量，计算24h氟、铝总摄入量和排出量；采用氟离子选择电极法和电感耦合等离子体质谱法（ICP—MS）检测饮用砖茶前空腹与饮用砖茶后0．5、1．0、2．0、3：0h及24．0h后空腹血清含氟、铝量。结果非病区健康人饮用砖茶前空腹与饮用砖茶后1．0、2．0、4．0、〉4．0～〈24．0h及24．0h后空腹尿含氟量分别为（0．50±0．14）、（2．14±0．90）、（1．57±0．93）、（2．43±1．49）、（1．91±0．69）、（0．58±0．20）mg／L，24h尿氟排泄率为52．85％（4：64／8．78）；尿含铝量分别为（0．35±0．15）、（0．65±0．37）、（0．50±0．25）、（0．52±0．21）、（0．50±0．23）、（0．46±0．27）mg／L，24h尿铝排泄率为12．38％（1．37／11．07）；饮用砖茶前空腹与饮用砖茶后0．5、1．0、2．0、3．0h及24．0h后空腹血清含氟量分别为（0．06±0．02）、（0．14±0．01）、（0．21±0．04）、（0．17±0．04）、（0．10±0．03）、（0．04±0．01）mg／L，血清含铝量分别为（0．30±0．05）、（0．27±0．01）、（0．30±0．12）、（0．34±0．19）、（0．30±0．10）、（0．27±0．09）mg／L。结论砖茶中的氟较易被人体吸收、贮留和排泄，砖茶中的铝吸收较少，通过肾脏经尿排泄率相对较低，尿氟、铝尤其是空腹尿氟、铝水平较为稳定，可作为饮茶型氟铝联合中毒病情监测、预防试验效果判定指标．血清氟、铝水平可作为中毒指标。Objective To observe the absorption, excretion and retention of fluoride and aluminum after drinking brick tea in healthy adults. Methods The study was conducted in ten healthy volunteers by drinking brick tea solution in which the fluoride and aluminum concentrations were 5.97, 7.53 mg/L, respectively. The concentrations of fluoride and aluminum were determined in serum samples collected before and at 0.5,1.0,2.0,3.0, and 24.0 h, and in urine samples collected before and during the periods 1.0,2.0,4.0, 〉 4.0 - 〈 24.0 h and 24 h after drinking brick tea solution by ion-selective electrode, inductively coupled plasma atomic emission spectrometry （ICP-AES） and inductively coupled plasma atomic mess spectrometry. The total amounts of intake and excretion of fluoride and aluminum in healthy volunteers during 24.0 h were calculated from their corresponding fluoride and aluminum ingesting from brick tea and excreting from urine. Results Before and during the periods 1.0,2.0,4.0, 〉 4.0 - 〈 24.0 h and 24.0 h after drinking brick tea solution, the urinary fluoride concentrations were （0.50 ± 0.14）, （2.14 ± 0.90）, （1.57 ± 0.93）, （2.43 ± 1.49）, （1.91 ± 0.69）, （0.58 ± 0.20）mg/L, respectively, and the aluminum concentrations in the urine samples were （0.35 ± 0.15）, （0.65 ± 0.37）, （0.50 ± 0.25）, （0.52 ± 0.21 ）, （0.50 ± 0.23）, （0.46 ± 0.27）mg/L, respectively; the 24.0 h excreting rates of fluoride and aluminum from urine ,were 52.90%（4.64/8.77） and 12.38% （1.37/11.07）, respectively. The fluoride concentrations in serum samples collected before and at 0.5,1.0,2.0,3.0,24.0 h after drinking brick tea solution were （0.06 ± 0.02）, （0.14 ± 0.0l）, （0.21 ± 0.04）, （0.17 ± 0.04）, （0.10 ± 0.03）, （0.04 ± 0.01）mg/L, respectively, and aluminum in those were （0.30 ± 0.05）, （0.27 ± 0.01）, （0.30 ± 0.12）, （0.34 ± 0.19）, （0.30 ± 0.10）, （0.27 ± 0.09）mg/L, respectively. Conclusions Fluoride in brick tea is easy

关 键 词：氟 铝 吸收 排泄 

分 类 号：R599[医药卫生—内科学]