格列美脲联合二甲双胍短期内强化治疗对初诊2型糖尿病疗效的观察  

Effect of short-term intensive therapy with glimepiride and metformin in newly diagnosed type 2 diabetic patients

作　　者：汪敏[1] 高方[2] 薛耀明[2] 韩亚娟[2] 符霞军[2] 何飞英[2] 

机构地区：[1]广州市胸科医院内分泌合并结核病科,广东广州510095 [2]南方医科大学南方医院内分泌代谢科,广东广州510515

出　　处：《南方医科大学学报》2011年第3期564-566,共3页Journal of Southern Medical University

摘　　要：目的对HbA1c>9%的新诊断的2型糖尿病患者进行12周的口服药物短期强化治疗,观察强化方案的疗效。方法对HbA1c>9%的新诊断的2型糖尿病患者进行格列美脲联合二甲双胍12周的短期强化治疗,观察疗效。结果治疗后FPG、2 h PG、HbA1c均显著下降(P<0.01);HOMA-IR下降、HOMA-B升高(P均<0.01);TG、CHOL、LDL均显著下降(P<0.01)。结论 HbA1c>9%的新诊断的T2DM患者格列美脲联合二甲双胍短期强化方案安全有效。Objective To evaluate the effect of short-term intensive therapy on blood glucose control,β-cell function,and blood lipid levels in newly diagnosed type 2 diabetic patients.Methods Out-patients with newly diagnosed type 2 diabetic patients were enrolled for intensive treatment with sulfonylureas and metformin for 12 weeks,and the therapeutic effect was evaluated.Results After the intensive treatment,FPG,2 hPG,and HbA1c decreased significantly（P0.01）;HOMA-IR decreased and HOMA-B increased significantly（P0.01）,and TG,CHOL,LDL decreased significantly（P0.01） after the treatment.Conclusion Short-term intensive treatment with glimepiride combined with metformin is safe and effective in newly diagnosed type 2 diabetic patients with HbA1c9%.

关 键 词：2型糖尿病 强化治疗 格列美脲 胰岛Β细胞功能 血脂 

分 类 号：R587.1[医药卫生—内分泌]