多溴二苯醚毒理学研究进展及展望  

Research Progress and Future Perspectives in Toxicology Study on Polybrominated Diphenyl Ethers

作　　者：颜世帅[1] 徐海明[1] 秦占芬[1] 

机构地区：[1]中国科学院生态环境研究中心环境化学与生态毒理学国家重点实验室,北京100085

出　　处：《生态毒理学报》2010年第5期609-617,共9页Asian Journal of Ecotoxicology

基　　金：中国科学院知识创新重要方向性项目 (No.KZCX2-YW-Q-02-05;No.KZCX2-YW-420-3);国家自然科学基金项目(No.20677074)

摘　　要：多溴二苯醚(PBDEs)虽然已在一些国家禁止生产和使用,商品五溴和八溴二苯醚也在2009年被列入《关于持久性有机污染物(POPs)的斯德哥尔摩公约》受控范围内,但目前学术界对PBDEs的毒理学效应及其机制尤其是环境剂量效应的认识并不十分清楚. 论文从甲状腺干扰、神经毒性、生殖内分泌干扰3个方面介绍了近年来PBDEs毒理学研究的进展,分析了该领域研究中存在的几个问题,提出今后应大力开展环境相关剂量下PBDEs及代谢物的毒性研究,以推进对实际环境中PBDEs真实毒性的认识;同时探索能够反映PBDEs毒性的非创性生物标记物,为开展PBDEs人体健康影响的流行病学调查提供线索.Polybrominated diphenyl ethers（PBDEs）have been banned in some countries, and pentaBDE and octaBDE were listed in Part I of Annex A of the Stockholm Convention on Persistent Organic Pollutants（POPs） in 2009. However, toxicological effects and toxicological mechanism of PBDEs have been still unclear, especially on toxicological effects of PBDEs at environmentally relevant doses. In this paper, we review recent research progress in toxicology study on PBDEs from three aspects including thyroid disruption, neurotoxicity and reproductive endocrine disruption, discuss several problems in this research field. Furthermore, we make a point that toxicological study of PBDEs and their metabolites at environmentally relevant doses should be strengthened to improve the understanding of PBDEs toxicities in actual environment. We also suggest that some non-invasive biomarkers indicating PBDEs toxicity should be established to provide clues for epidemiological study on health effects of PBDEs.

关 键 词：多溴二苯醚 神经毒性 甲状腺干扰 生殖内分泌干扰 代谢物 环境相关剂量 

分 类 号：R996[医药卫生—毒理学]