Plant as Bioreactor for Producing Heterologous Proteins  

作　　者：YANG Jing XIONG Li-dong LI Tian-hang GUO Yong-xin LI Hai-yan LI Xiao-kun 

机构地区：[1]Jilin Agricultural University, Ministry of Education Bioreactor and Drug Development Research Center,Changchun Jilin 130118, China [2]Jilin Agricultural University, College of Chinese Herbal Medicines, Changchun Jilin 130118, China [3]Jilin Agricultural University, College of Life Sciences, Changchun Jilin 130118, China

出　　处：《Chinese Journal of Biomedical Engineering(English Edition)》2010年第4期156-173,共18页中国生物医学工程学报（英文版）

基　　金：National Ministry of Science and Technology "836" Project; grant number:2007AA100503

摘　　要：Using plants to produce heterologous proteins makes it very attractive due to the potentially low costs. Using this procedure it is possible to produce medicinal protein for clinical applications with the plants bioreactors increasing gradually. The paper proposes the five major systems of the plant bioreactor as well as their advantage and disadvantage and the development of each system. Focuses on the five major systems of the plant bioreactor to produce vaccines, antibodies and medical protein and the research achievement at the present stage and the research on my laboratory. The key technology research of plant bioreactor such as new genes, new biological components, new technologies and new research methods related with plant bioreactor offer a work foundation for a long-term development in future.Using plants to produce heterologous proteins makes it very attractive due to the potentially low costs. Using this procedure it is possible to produce medicinal protein for clinical applications with the plants bioreactors increasing gradually. The paper proposes the five major systems of the plant bioreactor as well as their advantage and disadvantage and the development of each system. Focuses on the five major systems of the plant bioreactor to produce vaccines, antibodies and medical protein and the research achievement at the present stage and the research on my laboratory. The key technology research of plant bioreactor such as new genes, new biological components, new technologies and new research methods related with plant bioreactor offer a work foundation for a long-term development in future.

关 键 词：BIOREACTOR in planta oil body CHLOROPLAST suspension system plantvirus heterologous protein 

分 类 号：Q813[生物学—生物工程]