兔感觉神经植入失神经皮瓣后再生末梢支配面积的动态变化研究  

Dynamic observations of distribution of regenerated nerve endings in denervated flaps after the implantation of sensory nerves in rabbits

作　　者：杨帆[1] 陈绍宗[1] 李跃军[1] 

机构地区：[1]第四军医大学唐都医院整形科,陕西西安710038

出　　处：《第四军医大学学报》1999年第8期707-709,共3页Journal of the Fourth Military Medical University

摘　　要：目的：研究神经植入术后再生末梢支配面积的变化规律．方法：兔耳大神经植人颈肩部失神经皮瓣模型，利用神经单纤维放电引导、神经原性血浆外渗和抗NF抗体免疫组化技术，对3cm直径失神经皮瓣在植入1．5cm长耳大神经后不同时间对皮瓣获得神经再支配的面积进行测量．结果：术后lino再生末梢支配皮瓣面积的16％，3mo52％，5mo74％，8mo95％．三种实验方法结果相符．结论：神经植人术后再生末稍支配面积逐步扩大，3crn直径皮瓣植入1．5cm长外径为lmm的神经，术后8mo可获得充分的神经再支配．AIM: To study the innervation of the regenerated nerve endings after implantation. METHODS: Greater auricular nerves, 1. 5 cm in length, were implanted into denerved flap, which were 3 cm in diameter and transferred from cervical--shoulder to the back of rabbit ears. The innervated flaps were examined at different intervals with neuroelectrophysiological fiber discharge conduct, neurogenic plasma extravasation and neurofilament immunohistochemical tech'nique respectively. RESULTS: The area innervated by the regenerated nerve endings accounts for 16% of the whole flap by I month, 52% by 3 months, 74% by 5 months and 95% by & months. The three methods got almost the same results. CONCLUSION: The area innervated by the regenerated nerve endings gradually expands. When a nerve, 1 mm in diameter, is implanted into a flap, 3 cm in diameter, innervation will be fully regained & months after the operation.

关 键 词：神经移植 失神经皮瓣 神经再生 

分 类 号：R651.3[医药卫生—外科学] R622.1[医药卫生—临床医学]