电针不同经穴对不同性周期雌鼠黑质神经元放电的影响  

The Influence of Electropuncture of Different Acupoints on Discharge from Neurons in Sbustantia Nigra of Female Rats of Different Sex Cycles

作　　者：孙启新[1] 马庆龄[1] 朱笛霓[1] 李春敏[1] 

机构地区：[1]陕西省中医药研究院

出　　处：《上海针灸杂志》1999年第4期34-35,共2页Shanghai Journal of Acupuncture and Moxibustion

基　　金：陕西省卫生厅科研攻关课题

摘　　要：探讨不同经穴的镇痛作用及针刺镇痛中多巴胺（ＤＡ）与性激素的关系。方法在去卵巢（ＯＶＸ）大鼠和ＯＶＸ加注雌二醇（ＯＶＸ＋Ｅ２）大鼠黑质（ＳＮ）神经元的自发放电和几种刺激的诱发反应之后，分别电针“肾俞”或“三阴交”两穴，以观察电针不同经、穴对上述反应的影响。结果电针“三阴交”后，两组自发放电均趋抑制；而电针“肾俞”后，两组放电均有不同程度激活。结论经、穴对同一ＳＮ单位的不同作用表明经、穴是相对独立存在的，各经、穴分别产生不同的调节机制；针刺在镇痛过程中可能对体内的激素水平、镇痛系统和递质系统产生了复杂的综合调节作用。Objective To investigate the analgetic effect of different acupoints of regular channels and the relation between dopamine (DA) and sexual hormones in acupuncture analgesia. Methods After spontaneous discharge from and the induced reactions to several stimulations of neurons in sustantia nigra (SN) of ovariectomized (OVX) rats and OVX rats injected with estradiol,points shenshu (B23) and Sanyinjiao (SP6) were respectively electropunctured to observe the influence of electropuncture of different channels and acupoints on the above reactions. Results After electropuncture of Sanyinjiao,spontaneous discharge tended to be inhibited;after electropuncture of Shenshu,discharge was activated in varying degrees,in the two groups. Conclusion The differences in spontaneous discharge from and induced reactions of SN neurons among different levels of sexual hormones reflect the influence of sexual hormones on dopamine (DA) neurons;The different effects of different channels and points on the identical SN unit show the relatively independent existence of channels and points,and the different mechanisms of regulation by various channels and points;the different effects of the two channels and the two points on SN units indicate that acupuncture may produce a complex and comprehensive adjusting effect on the body's hormone level,analgetic system and transmitter system during analgesia.

关 键 词：电针 黑质 多巴胺 神经元 性激素 针刺镇痛 

分 类 号：R246.2[医药卫生—针灸推拿学]