Synthesis of mono-substituted derivatives of 6-aminoquinoline  

作　　者：Tian Lan Xian Xia Yuan Jiang Hong Yu Chao Jia Yu Shi Wang Hui Juan Zhang Zi Feng Ma Wei Dong Ye 

机构地区：[1]School of Chemistry and Chemical Engineering, Shanghai Jiaotong University, Shanghai 200240, China [2]School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China [3]Xinchang Pharmaceutical Factory, Zhejiang Pharmaceutics Co. Ltd., Xinchang 312500, China

出　　处：《Chinese Chemical Letters》2011年第3期253-255,共3页中国化学快报（英文版）

基　　金：the financial support of this work by the National Science Foundation of China(No 20776085);the 973 Program of China(No2007CB209700);the STCSM of China(Nos10JC1406900 and 09XD1402400);the Foundation of Zhejiang Pharmaceutics CoLtd ;the Opening Foundation of Zhejiang Provincial Top Key Discipline

摘　　要：Several 6-aminoquinoline derivatives,which could be used in drug design,have been synthesized.The reaction conditions were comparatively studied,and the p-chloroaniline was used as optimum oxidant in Skraup-Doebner-Von Miller reaction.The nitro group was reduced effectively by SnCl2 with no halo-removed occurred.Several 6-aminoquinoline derivatives,which could be used in drug design,have been synthesized.The reaction conditions were comparatively studied,and the p-chloroaniline was used as optimum oxidant in Skraup-Doebner-Von Miller reaction.The nitro group was reduced effectively by SnCl2 with no halo-removed occurred.

关 键 词：6-Aminoquinoline 6-Nitroquinoline Skraup reaction OXIDANT 

分 类 号：TQ612.1[化学工程—精细化工] O626.323[理学—有机化学]