正弦调制中频电流治疗肾衰的实验研究  

Modulated medium frequency sinusoidal electrotherapy for renal failure in rabbits model

作　　者：韩玉芹[1] 史永明[1] 周庚寅[1] 王艳君 管宜君 

机构地区：[1]山东医科大学附属一院康复科

出　　处：《中华理疗杂志》1999年第4期221-223,共3页Chinese Journal of Physical Therapy

摘　　要：目的探讨正弦调制电流对实验性肾功衰竭的治疗作用。方法家兔３８只随机分为治疗组和对照组，实验前和实验中隔日测２４小时尿量、尿肌酐、血清肌酐、肌酐清除率、尿素氮。实验开始每天给家兔肌肉注射庆大霉素１００ｍｇ／ｋｇ，连续注射８天。实验组采用正弦调制中频电流治疗，对照组不予任何治疗。治疗１０次后处死动物进行病理组织学观察。结果治疗后五项肾功能指标治疗组均较对照组轻。对照组在第６和第８天五项肾功能指标差异均有显著性，而治疗组中仅有二项指标（尿素氮、血肌酐）在第８天和第１０天有显著性改变。病理组织学检查，对照组出现明显的肾小球毛细血管丛细胞坏死，肾小管明显扩张坏死，管腔大量蛋白管型，治疗组上述改变较轻。结论正弦调制中频电流对实验性肾衰有治疗和预防作用。Objective To observe the effect of modulated frequency sinusoidal electrotherapy on experimental renal failure in rabbits.Methods 38 rabbits were equally separated two groups.The urine volume/24h, urinary creatine, serum creatine, creatine clearance rate and BUN were assayed before the test,every other day during the test. The experimental rabbits were formed the renal failure with gentamycin injection(100 mg/kg,I.M)/per day for eight days consecutively. The rabbits of treatment group were treated with modulated medium frequency sinusoidal electrotherapy 10 times. The control group was without any treatment. After experiment,these rabbits were killed for histopathology examination.Results After treatment,the five parameters of renal function in treatmet group were better than those of control group.Moreover,in control group,the five parameters at 6th, 8th day were compared with those of pre-experiment,threr was a significant difference.The BUN and serum creatine at 8th, 10th day after experiment in treatment group had presnted a obvious changes.On histopathology,the cytonecrosis of glomerular capillary loop and renal tubules,protein casts in renal tubules in treatment group were also better than the control group.Conclusion It is indicated that the modulated medium frequency sinusoidal electrotherapy has treatment and prevention for the renal failure.

关 键 词：肾功能衰竭 正弦调制 中频电流 电疗法 

分 类 号：R692.505[医药卫生—泌尿科学] R454.1[医药卫生—外科学]