原发性高血压血清胰岛素样生长因子-1的临床研究  

Clinical Studies of Insulin like Growth Factor 1 in Essential Hypertension

作　　者：卜培莉[1] 王淑贞[1] 张运[1] 张梅[1] 黎莉[1] 李传义[1] 郑昭伦[1] 钟明[1] 

机构地区：[1]山东医科大学附属医院,山东省济南市250012

出　　处：《中国循环杂志》1999年第4期196-197,共2页Chinese Circulation Journal

基　　金：山东省自然科学基金;青年基金

摘　　要：目的：观察原发性高血压患者胰岛素样生长因子－１（ＩＧＦ－１）血清水平与原发性高血压及原发性高血压合并左心室肥厚（ＬＶＨ）的关系。　　方法：对３８ 例原发性高血压患者进行超声心动图检查，确定有无ＬＶＨ及左心室舒张功能减低，同时用放射免疫法测定其血清中ＩＧＦ－１的浓度，根据有无合并ＬＶＨ，将３８ 例原发性高血压患者分为单纯原发性高血压组（ｎ＝ ２０），原发性高血压合并ＬＶＨ组（ｎ＝ １８）。另选２４ 例正常人为正常对照组，比较３ 组之间血清ＩＧＦ－１ 水平。　　结果：原发性高血压合并ＬＶＨ组血清ＩＧＦ－１水平高于正常对照组（２４７．９±４６．４ ｖｓ．２０８．４±６１．７，Ｐ＜ ０．０５），左心室重量指数（ＬＶＭＩ）与血清ＩＧＦ－１中度相关（ｒ＝ ０．４１，Ｐ＜ ０．０５）。　　结论：ＩＧＦ－１可能参与了原发性高血压ＬＶＨ的发生发展过程。Objective:To observe the changes of serum insulin like growth factor 1(IGF 1) in essential hypertension and patients with essential hypertensive left ventricular hypertrophy(LVH). Methods:Thirty eight patients with essential hypertention and twenty four normal subjects were studied using echocardiogrophy to determined LVH and left ventricular diastolic disfunction.The surum IGF 1 was measured by radiommenoassay. Results:The serum IGF 1 in the group of essential hypertension with LVH was increased than the normal subject group(247 9±46 4 vs.208 4±61 7, p <0 05).There was a positive correlation between the serum IGF 1 and left ventricular mass index(LVMI, r =0 41, p <0 05). Conclusion:The increased serum IGF 1 may be involved in the occurance and development of essential hypertension associated LVH.

关 键 词：高血压 左心室肥厚 IGF-1 

分 类 号：R544.1[医药卫生—心血管疾病] R541.3[医药卫生—内科学]