原发性高血压患者尿α_1-微球蛋白、转铁蛋白的变化及非洛地平对其的影响  

The Effect of Felodipine on Urinary α 1 Microglobulin,Transferrin in Essential Hypertensive Patients

作　　者：万大国[1] 李莉[1] 崔天祥[1] 孙铭毅 崔明琴[1] 刘宗芳[1] 胡亚兰 

机构地区：[1]河南医科大学第二附属医院心内科,河南省郑州市450003 [2]郑州银河股份有限公司职工医院 [3]中原制药厂医务所

出　　处：《中国循环杂志》1999年第4期213-215,共3页Chinese Circulation Journal

基　　金：河南省科技攻关项目

摘　　要：目的：研究原发性高血压（ＥＨ）患者尿蛋白的排泄情况及非洛地平对其的影响。　　方法：测定３０ 例正常人（正常对照组）及６０ 例ＥＨ患者（ＥＨ组，其中包括轻度ＥＨ组３２例、中度ＥＨ组２８例）用药前后的尿α１－微球蛋白、转铁蛋白及血清肌酐。　　结果：①轻度ＥＨ组尿α１ －微球蛋白、转铁蛋白明显高于对照组（Ｐ＜ ０．０１），中度ＥＨ组尿α１－微球蛋白、转铁蛋白明显高于轻度ＥＨ组和正常对照组（Ｐ＜ ０．０１；Ｐ＜ ０．００１），且与病程有关。②血清肌酐在中度ＥＨ组明显高于正常对照组（Ｐ＜ ０．０５），轻度ＥＨ组较正常对照组无明显升高（Ｐ＞ ０．０５）。③非洛地平治疗后，轻度、中度ＥＨ组尿α１ －微球蛋白、转铁蛋白较治疗前明显降低（Ｐ＜ ０．０１；Ｐ＜ ０．００１），轻度ＥＨ组血清肌酐较治疗前无明显降低（Ｐ＞ ０．０５），而在中度ＥＨ组血清肌酐较治疗前明显下降（Ｐ＜ ０．０５）。　　结论：尿α１ －微球蛋白、转铁蛋白较血清肌酐能更早的识别高血压肾脏损害，非洛地平降压的同时能预防或延缓肾脏损害的发生、发展。Objective:To study the changes of proteinuria in essential hypertensive patients and the effect of felodipine therapy. Methods:The concentration of urinary α 1 microglobulin,transferrin and serum creatinine in 60 essential hypertensive patients and 30 normal persons were mearured,their changes before and after felodipine treatment were mone fored. Results:1.The concentration of urinary α 1 microglobulin,transferrin in mild and moderate essential hypertensive group were significantly higher than that in the control group( p <0 01; p <0 001),the concentration of urinary α 1 microglobulin,transferrin in moderate essential hypertensive group were significantly higher than that in the mild essential hypertensive group( p <0 01).The duration of essential hypertension influences the concentration of urinary α 1 microglobulin,transferrin.2.There was no significant difference of serum creatinine concentration between mild essential hypertensive group and control group( p >0 05),the serum creatinine concentration in moderate essential hypertensive group was significantly higher than that in the control group( p <0 05).3.The concentration of urinary α 1 microglobulin,transferrin in mild and moderate essential hypertensive group after treatment were significantly lower than that before treatment( p <0 01; p <0 001),there was no significant difference of serum creatinine concentration in mild essential hypertension group between before and after treatment ( p >0 05),the concentration of serum creatinine in moderate essential hypertension group after treatment was significantly lower than that before treatment( p <0 05). Conclusion:Detection of urinary α 1 microglobulin,transferrin may identify hypertensive kidney injury earlier than detection serum creatinine,felodipine can protect and retard the occurence and progression of kidney injury besides its antihypertensive effect.

关 键 词：高血压 Α1-微球蛋白 转铁蛋白 非洛地平 治疗 

分 类 号：R544.105[医药卫生—心血管疾病] R972.4[医药卫生—内科学]