阿托伐他汀对高血压患者肾损害的影响  

THE EFFECT OF ATORVASTATIN ON HYPERTENSIVE PATIENTS WITH RENAL DAMAGE

作　　者：郭宇红[1] 王珏辉[1] 

机构地区：[1]河南省郑州铁路职业技术学院护理系,郑州450052

出　　处：《现代预防医学》2011年第7期1358-1359,共2页Modern Preventive Medicine

摘　　要：[目的]探讨阿托伐他汀对高血压患者肾损害的影响。[方法]选取血压控制达标的高血压并微量白蛋白尿患者100例,随机分为治疗组和对照组,治疗组予以阿托伐他汀20mg/d,对照组加用安慰剂治疗,两组治疗前及治疗后12周采用速率散射比浊法检测尿微量白蛋白(mAlb)、β2-微球蛋白(β2-MG),全定量酶免疫法测定尿视黄醇结合蛋白(RBP),速率法检测N-乙酰-β-D氨基葡萄糖苷酶(NAG),Jaffe速率法测定尿肌酐。[结果]治疗组患者RBP、mAlb、β2-MG、NAG均较治疗前和对照组治疗后显著下降,差异均有高度统计学意义(均P﹤0.01),无严重不良反应。[结论]阿托伐他汀能减轻高血压患者肾损害及改善肾功能。[Objective]To investigate the effect of atorvastatin on blood pressure in patients with renal damage.[Methods]Selected 100 cases of blood pressure control achieved standard with high blood pressure and microalbuminuria,then randomly divided into treatment group and control group.The treatment group was given to atorvastatin 20 mg/d,control group was given with placebo treatment.Before treatment and 12 weeks after treatment,used rate nephelometry to assay urinary albumin（mAlb）,β2-microglobulin（β2-MG）,and quantitative determination of enzyme immunoassay to detect retinol-binding protein（RBP）,the rate detection to dicover N-acetyl-β-D-glucosaminidase（NAG）,Jaffe rate method to test urinary creatinine in two groups.[Results]In the treatment group,patients＇ RBP,mAlb,β2-MG,NAG decreased significantly after treatment,comparing those before treatment and the control group,the differences were statistically significant（all P﹤0.01）,and without serious adverse reactions.[Conclusion]Atorvastatin can reduce renal damage in patients with hypertension and improve renal function.

关 键 词：阿托伐他汀 高血压 微量白蛋白 Β2-微球蛋白 视黄醇结合蛋白 N-乙酰-Β-D氨基葡萄糖苷酶 

分 类 号：R544.1[医药卫生—心血管疾病] R972.4[医药卫生—内科学]