人工肝支持系统治疗重型肝炎的临床研究  

Clinical Study of Artifical Liver Support System to Patients with Severe Hepatitis

作　　者：黄莹[1] 曾健伟[1] 古英明[1] 

机构地区：[1]广州医学院第二附属医院,广州510260

出　　处：《透析与人工器官》2010年第4期1-4,共4页Chinese Journal of Dialysis and Artificial Organs

摘　　要：目的探讨人工肝支持系统(artifical liver support system,ALSS)治疗重型肝炎的临床疗效。方法对33例重型肝炎患者在内科基础治疗上,给予71例次人工肝支持治疗,其中血浆置换(plasma exchange,PE)治疗17例,共37例次,血浆灌流(plasma perfusion,PP)治疗16例,共34例次。治疗前后检测胆红素、转氨酶、血氨、白蛋白、凝血时间等指标,并观察临床症状。结果经ALSS治疗后,患者食欲增加,腹胀、乏力减轻,精神明显好转,近期临床总有效率为45.45%。同时对血浆置换和血浆灌流进行疗效比较发现,血浆置换和血浆灌流均能有效清除高胆红素血症,降低转氨酶。血浆置换在降低血氨水平和改善凝血功能方面优于血浆灌流。结论 ALSS是治疗重型肝炎的一种有效安全的方法,可根据病情选用不同方法尽早使用。Objective To study the clinical efficacy of artifical liver support system in treating the patients with severe hepatitis.Methods Treat 33 severe hepatitis cases with artifical liver support system for 71 times,before and after the treatment,symptoms and signs of all patients and liver function,anticoagulation function were observed closely.Results After the treatment of ALSS,the symptons and manifestation of patients improved,the total effectiveness was 45.45%.Serum total bilirubin（TBIL）,alanine am ino-transferase（ALT） decreased after the treatment of PE and PP.Compared with PP,the PE decreased serum NH3 and improved hemoglutination more effectively.Conclusion ALSS is an effective and safe treatment for severe hepatitis,we may select the different methods according to the condition to use as soon as possible.

关 键 词：人工肝支持系统 重型肝炎 血浆置换 血浆灌流 

分 类 号：R692.5[医药卫生—泌尿科学]