高血压脑出血微创血肿清除术后血清TNF-α及IL-6的动态变化  

The Serum Dyanmic Change of TNF-α and IL-6 by Mini-invasive Aspiration in Patients with Hypertensive Intracerebral Hemorrhage

作　　者：周汝娟[1] 何龙锦[1] 徐武[1] 杨峰[1] 丁春琴[1] 

机构地区：[1]泰兴市人民医院神经内科,江苏泰兴225400

出　　处：《苏州大学学报（医学版）》2010年第6期1268-1270,共3页Suzhou University Journal of Medical Science

摘　　要：目的探讨高血压脑出血患者血清肿瘤坏死因子-α(TNF-α)和白介素-6(IL-6)的动态变化及微创血肿清除术对两者的影响。方法分别采用放免法和ELISA法检测48例高血压脑出血患者(分为微创术组和内科组)出血后第1天及治疗后第2、7、14天血清TNF-α和IL-6含量,并测定两组治疗前、治疗后第14天中国中风神经功能缺损评分(CSS)。结果治疗前两组TNF-α、IL-6含量及CSS比较,差异均无统计学意义(P>0.05),术后第14天时微创术组的TNF-α、IL-6水平和CSS分值明显低于内科组(P<0.05)。结论微创血肿清除术可抑制或减轻急性脑出血患者TNF-α、IL-6的急剧增加,对改善脑损伤程度、减少炎症及免疫反应具有较高的应用价值。Objective To observe change of serum tumor necrosis factor-α（TNF-α） and interleukin-6（IL-6） and the influence by mini-invasive aspiratio in the patients with hypertensive intracerebral hemorrhage.Methods Serum TNF-α and IL-6 levels in 48 cases of hypertensive intracerebral hemorrhage（aspiration group and conservative group） were measured by radioimmunity methods and ELISA 1 day and 2,7 and 14 days after cerebral hemorrhage.China stroke scale（CSS） score were observed on the first day and fourteenth day.Results There was no significant difference between the two groups in the TNF-α,IL-6 and CSS in the first day（P0.05）.AT the 14th day,the TNF-α,IL-6 and CSS scores showed a remarkable improvement in the aspiration group（P0.05）.Conclusion Mini-invasive aspiration could reduce the serum concentration of TNF-αand IL-6 and inhibit the inflammatory response.

关 键 词：高血压脑出血 微创血肿清除术 肿瘤坏死因子-α 白介素-6 

分 类 号：R544.106[医药卫生—心血管疾病]