“一锅法”合成(芳氨基甲基)苯酚  

One-pot synthesis of arylaminomethyl phenols

作　　者：唐子龙[1] 常书红[1] 张超逸[1] 颜林[1] 刘汉文[1] 

机构地区：[1]湖南科技大学化学化工学院理论化学与分子模拟省部共建教育部重点实验室分子构效关系湖南省普通高校重点实验室,湖南湘潭411201

出　　处：《华中师范大学学报（自然科学版）》2011年第1期63-67,共5页Journal of Central China Normal University：Natural Sciences

基　　金：国家自然科学基金项目(21042011);湖南省教育厅重点科研项目(10A034);中国博士后科学基金项目(20100471228);湖南省博士后科学基金项目(2010RS4033)

摘　　要：采用"一锅法"和分步法以芳氨、水杨醛或对羟基苯甲醛为原料合成了一系列芳氨基甲基苯酚.由前者所得到化合物的产率高于后者,并且发现对于两种合成方法,目标化合物的产率都与N原子相连的芳环上取代基的性质密切相关:OCH_3>CH_3>H>Cl."一锅法"操作步骤少,溶剂的使用量和废物的排放量也得到相应减少,符合绿色化学的要求."一锅法"是非常简单和有效合成取代氨基甲基苯酚类化合物的方法.目标化合物的结构用IR,~1H NMR,^(13)C NMR等进行了分析与表征.A series of arylaminomethyl phenols were prepared by ＂one-pot＂ process and frac- tional step methods using salicylaldehyde or 4 hydroxybenzaldehyde and substituted anilines as starting materials. The products were obtained in higher yields with ＂one-pot＂ synthesis meth- od. For both methods, the yields had closed relationship with the substituents on the phenyl group connected with the nitrogen atom： OCH3〉 CH3〉 H 〉C1. But, the ＂one-pot＇＇ process was much simpler, cost less solvent and produced less waste than the fractional step method, and is very efficient and practicable for the synthesis of substituted aminomethylphenols. The structures of the products were characterized by IR,1H NMR,13C NMR.

关 键 词：芳氨基甲基苯酚 合成 一锅法 

分 类 号：O625.63[理学—有机化学]