卡马西平诱发药疹与HLA-B在汉族人群中的关系  

Carbamazepine-induced Drug Eruption of Epidermolysis Bullosa Associated with HLA-B*1502 Allele in Han Chinese

作　　者：曹志豪[1] 骆肖群[1] 

机构地区：[1]复旦大学附属华山医院皮肤科,上海200040

出　　处：《医学综述》2011年第6期923-925,共3页Medical Recapitulate

摘　　要：Stevens-Johnson综合征(SJS)和中毒性表皮坏死松解症(TEN)是一类发病率低却可危及生命的皮肤不良反应,卡马西平(CBZ)是常见诱发药物之一。近年来许多地区报道HLA-B*1502与CBZ在汉族人群中诱发SJS和TEN强相关,而在高加索人种中却没有类似发现,存在种族差异。目前CBZ仍然是临床中常用药物。现对CBZ诱发SJS和TEN与HLA-B*1502在汉族人群的关系进行综述,为临床用药安全性提供参考。Stevens-Johnson syndrome（SJS）and toxic epidermal necrolysis（TEN）are rare but life-threatening severe cutaneou adverse reactions.One of the drugs most frequently associated with SJS/TEN is cabamazepine.Recently,strong association between HLA-B＊1502 and carbamazepine-indeced SJS and TEN have been found in Chinese Han population,but not in Caucasian.Ethinicity might be a risk factor.Carbamazepine is prescribed in clinical work currently,the objective of this study is to review accociation HLA-B＊1502 with carbamazepine-indeced SJS/TEN in Chinese Han population and provide reference for drug safety.

关 键 词：STEVENS-JOHNSON综合征 中毒性表皮坏死松解症 HLA-B＊1502 汉族 药疹 

分 类 号：R758.25[医药卫生—皮肤病学与性病学]