参麦注射液合缩合葡萄糖氯化钠注射液对创伤失血性休克早期凝血功能的影响  

Significance of monitoring coagulation function of the early traumatic hemorrhagic shock

作　　者：郭福东[1] 张立华[1] 于凤颖[1] 刘志强[2] 张大辉[1] 张亚通[3] 杨永丰[1] 

机构地区：[1]河北大学附属医院急诊外科,河北保定071000 [2]河北省保定市第一中心医院放射科,河北保定071000 [3]河北省保定市雄县医院急诊科,河北保定071800

出　　处：《河北中医》2011年第2期181-183,共3页Hebei Journal of Traditional Chinese Medicine

摘　　要：目的探讨应用参麦注射液合缩合葡萄糖氯化钠注射液对创伤失血性休克早期患者凝血功能的影响。方法将108例创伤失血性休克早期患者随机分为2组,治疗组55例第1条液路给予参麦注射液20～60 mL,加入5%葡萄糖注射液250 mL中,30 min内快速静脉滴注完成;第2条液路给予缩合葡萄糖氯化钠注射液500 mL,快速静脉滴注,之后给予晶体液滴入(贺斯等液体)。对照组53例第1条液路给予5%葡萄糖注射液250 mL,滴速与治疗组相同;第2条液路同治疗组。每30 min抽血化验并记录凝血酶原时间(PT)、活化的部分凝血酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)和血小板计数(PLT)变化,共记录4次(用药前和用药后30、609、0 min各记录1次)。结果治疗组用药后90 min PT、APTT、TT及PLT均较本组用药前、对照组同时期升高(P<0.05),FIB均降低(P<0.05)。治疗组用药后60 min APTT及TT均较对照组同时期升高(P<0.05)。结论参麦注射液合缩合葡萄糖氯化钠注射液治疗创伤失血性休克早期患者可有效降低血液黏度,纠正高凝状态,改善微循环,控制休克的进一步发展。Objective To explore the effects of Shenmai injection combined with Polyglucose sodium chloride injection on the coagulation function of the early traumatic hemorrhagic shock.Method 108 traumatic hemorrhagic shock patients in early stages were divided into two groups randomly.55 cases in the treatment group were treated with Shenmai injection 20~60 mL and 5% glucose 250 mL dropped into vein in 30 min,the other road dropped Polyglucose sodium chloride 500 mL.The treatment in control group（n=53） was as same as the treatment group only don＇t drop Shenmai injection.The above-mentioned targets were all written down one time per 30 min from the beginning of fluid transport therapy.The coagulation indexes including PT,APTT,TT,FIB and PLT were detected in 30 min,60 min and 90 min after treatment.Results PT,APTT,PLT and TT in two groups were increased,and FIB was decreased after treatment（P0.05）.There was difference between two groups on APTT and TT 60 min after treatment（P0.05）,on PT,PLT,FIB,APTT and TT 90 min after treatment（P0.01）.Conclusion The combined therapy of Polyglucose sodium chloride injection and Shenmai injection can effectively reduce blood viscosity,correct hypercoagulabale state,improve microcirculation and control the progress of shock.

关 键 词：休克 创伤性 休克 出血性 外科学 中西医结合疗法 

分 类 号：R605.971[医药卫生—急诊医学] R605.972[医药卫生—外科学]