二硫化碳作业女工早早孕丢失的研究  

Very early pregnancy loss of women occupationally exposed to carbon disulphide

作　　者：王志萍[1] 侯光萍[2] 李佩贤[1] 张呈祥 韩连堂[1] 杜继胜 张广学[1] 崔群[1] 邱玉刚[1] 任永清[2] 洪舜华[1] 王崇伟 

机构地区：[1]潍坊医学院 [2]潍坊市人民医院 [3]潍坊化纤厂职工医院

出　　处：《中华劳动卫生职业病杂志》1999年第4期204-207,共4页Chinese Journal of Industrial Hygiene and Occupational Diseases

摘　　要：目的　探讨二硫化碳（ Ｃ Ｓ２） 对作业女工孕早期胚胎发育的影响。方法　采用早早孕丢失为观察指标进行了研究，在观察期间共征集到１３９ 名欲要生育的女工，于每个月经周期２１ 天开始收集晨尿及隔日晨尿，至月经来潮或临床确诊妊娠止，共３４０ 个月经周期，２ ０４５ 份尿样，单克隆酶免方法定量测定尿样中绒毛膜促性腺激素含量。结果　接触组女工早早孕丢失率为４８ ．７ ％ ，明显高于对照组（２６ ．３ ％ ， Ｐ＝ ０ ．００４ １） 。夫妻双方均接触 Ｃ Ｓ２ 时，早早孕丢失率明显升高（ Ｐ＝ ０ ．００７ ４） 。作业地点 Ｃ Ｓ２浓度与早早孕丢失率相关（ ｒ ＝ ０ ．９９９ ， Ｐ＝ ０ ．００１） 。结论　接触 Ｃ Ｓ２ 的女工早早孕丢失的危险性升高， Ｃ Ｓ２ 浓度与早早孕丢失率之间有明显的剂量反应关系。Objective Very early pregnancy loss was used to reveal the effects of carbon disulphide( C S2) on early fetal develop ment . Methods Urine specim ens ofim plantation were collected fro m 61 wo menexposed to C S2 and 78 wo men served as control. All wo men were healthy and attem pted to conceive . Urinaryconcentrations of hum an chorionic gonadotropin(h C G) were measured for a total of 340 m entrual cycles of2 045 specim ens by h C G m ono clonal enxzym e im munom etric assay . Results 78 pregnancies in exposedgroup and 76 in control were identified by the h C Glevelin urine near the expected tim e of im plantation . Theprobabilities of gestation were 41 .7 % and 49 .7 % respectively ( P > 0 .05) . Early pregnancy loss were48 .7 % in exposed group and 26 .3 % in control,and 52 .5 % for couples exposed to C S2 that was significantlyhigher than that of couples did not contact any known hazards( P= 0 .007 4) . There was a definitely dose re sponse relationship between the level of C S2 in air at working place and the ratios of very early pregnancy loss( r = 0 .999 , P= 0 .001) . Conclusion Alm ost half of pregnancies were very early pregnancy loss in fem aleworkers exposed to C S2 .

关 键 词：二硫化碳 早早孕丢失 HCG 生殖毒性 

分 类 号：R135.1[医药卫生—劳动卫生]