米非司酮抗大鼠孕卵着床的形态学研究  

Morphological Study of Antiimplantation with Mifepristone in Rats

作　　者：李晓艳[1] 胡伦颖[2] 高秉兰[2] 

机构地区：[1]同济医科大学附属协和医院妇产科,武汉430022 [2]湖北医科大学附属第二医院妇产科,武汉430071

出　　处：《同济医科大学学报》1999年第4期329-331,共3页Acta Universitatis Medicinae Tongji

摘　　要：观察了大鼠妊娠第１ ｄ 或第１、２ ｄ 应用不同剂量米非司酮对着床的影响和用药后不同时间子宫内膜和卵巢黄体的形态学变化。结果表明： （１） 大鼠妊娠第１ ｄ 皮下注射米非司酮１０ ｍ ｇ／ｋｇ 可完全抗着床； （２） 妊娠第１ ｄ 或第１、２ ｄ 给予米非司酮致妊娠第８ ｄ 子宫内膜、黄体呈现不同程度空泡变性； （３） 完全抗着床剂量用药后３６ ｈ 子宫内膜超微结构出现不同程度的改变。提示：米非司酮对大鼠具有较强的抗着床作用，用药后子宫内膜细胞变性及大量炎性细胞浸润可能是米非司酮抗鼠孕卵着床作用发生的重要因素。The effect of mifepristone on antiimplantation in rats and morphological change of endometrium and corpus luteum were observed. Mifepristone was administered subcutaneously to rats on day 1 or days 1,2 of pregnancy. Higher dose (>10 mg/kg) administered on day 1 reduced the number of implantations to zero in all animals. The endometrium and corpus luteum showed degeneration under a microscope at 8th day of pregnancy when treated with mifepristone on day 1 or days 1,2 of pregnancy. The ultrastructure of endometrium showed changes under a transmission electron microscope 36 h after treated with mifepristone (10 mg/kg) on day 1 of pregnancy. These findings demonstrate that mifepristone can effectively inhibit the implantation in rats and that the degeneration of endometrium and corpus luteum and the infiltration of many leucocytes after treatement may be the important reasons for antiimplantation of mifepristone in rats.

关 键 词：米非司酮 着床 大鼠 形态学 抗着床作用 

分 类 号：R979.2[医药卫生—药品] R169.42[医药卫生—药学]