1,4-二(4-甲酰氯基苯甲酰基)苯的合成与表征  

The Synthesis and Characterized 1,4-Di(4-Chloro Formyl Benzoyl) Benzene

作　　者：祝志芳[1] 钟鸣[1] 易志群[1] 余雯雯[1] 宋琤[1] 宋才生[1] 

机构地区：[1]江西师范大学化学化工学院,江西南昌330022

出　　处：《江西师范大学学报（自然科学版）》2011年第1期21-23,共3页Journal of Jiangxi Normal University(Natural Science Edition)

基　　金：江西省自然科学基金(2008~2010);科技型中小企业技术创新基金(06C26213601342)资助项目

摘　　要：以甲苯、对苯二甲酰氯(TPC)为原料,无水三氯化铝为催化剂,通过亲电取代反应合成1,4-二(4-甲基苯甲酰基)苯(DMBB),产率为82%.在吡啶/水混合体系中用高锰酸钾将DMBB氧化得到1,4-二(4-甲羧基苯甲酰基)苯(DMBA),产率为85%.DMBA与二氯亚砜在DMF催化下反应合成1,4-二(4-甲酰氯苯甲酰基)苯(DMBC),产率为85%.3步总产率为59%.用FT-IR、1H NMR和元素分析等对化合物进行了表征.研究表明:化合物具有预期的结构和较高的纯度.A novel compound 1,4-di（4-methylbenzoyl）benzene （DMBC） was synthesized with terephthaloyl chloride （TPC） and toluene by Friedel-Crafts electrophilic aromatic substitution in the presence of anhydrous aluminum chloride as a catalyst. The yield of DMBB was 82%. Then 1,4-di（4-carboxyl benzoyl）benzene （DMBB） was obtained from DMBA by catalytic oxidation in the mixture of pyridine and water and potassium permanganate as oxidation agent. The yield of DMBA was 85%. 1,4-di（4-chloro formyl benzoyl）benzene DMBC was prepared by acidylated the DMBB with thionyl chloride as a acylating agent and N,N-dimethylformamide（DMF） as a catalyst. The yield of DMBC was 85%. The overall yield of the three-step reaction for DMBC was 59%. The chemical structure was characterized by FT-IR, 1↑H NMR and elemental analysis. The results showed that compound obtained as expected.

关 键 词：1 4-二(4-甲酰氯苯甲酰基)苯 氧化 酰化 合成 

分 类 号：O623.62[理学—有机化学]