大籽獐牙菜 酮的研究  

Studies on the Xanthones from Swertia macrosperma C.B.Clark

作　　者：熊成文[1,2] 林鹏程[1] 

机构地区：[1]青海民族大学,西宁810006 [2]青海省药品检验所,西宁810016

出　　处：《北方药学》2011年第1期16-17,共2页Journal of North Pharmacy

摘　　要：目的:研究藏药大籽獐牙菜Swertia macrosperma C.B.Clark全草的化学成分。方法:运用硅胶柱层析和高效液相色谱方法进行化学成分的分离纯化,通过理化常数和波谱分析鉴定化合物结构。结果:从大籽獐牙菜的80%乙醇提取物中分离得到6个酮化合物,分别鉴定为1,7,8-trihydroxy-3-methoxyxanthone(Ⅰ)、1-hydroxy-3,7,8-trimethoxyxanthone(Ⅱ)、1,8-dihydroxy-3,7-dimethoxyxanthone(Ⅲ)、1,7-dihydroxy-3,8-dimethoxyxanthone(Ⅳ)、1,5,8-trihydroxy-3-methoxyxanthone(Ⅴ)、mangiferin(Ⅵ)。结论:上述化合物Ⅰ、Ⅳ为首次从大籽獐牙菜中分离得到。Objective：To investigate the xanthones from Swerfia macrosperma C.B.Clark.Methods：The xanthones were isolated by silica gel column chromatography and HPLC,and their structures were elucidated by spectral analysis.Results：Six xanthones were isolated from 80% ethanol extract and their structures were elucidated as 1,7,8-trihydroxy-3-methoxyxanthone（ Ⅰ ）,l-hydroxy-3,7,8-trimethoxyxan- thone（ Ⅱ ）,1,8--dihydroxy-3,7-dimethoxyxanthone （ Ⅲ）,1,7-lihydroxy-3,8-dimethoxyxanthone（ Ⅳ ）,1,5,8-trihydroxy-3-methoxyxanthone（ V ）,mangiferin（Ⅵ）.Conclusion：Compound Ⅰ and Ⅳ are islated from Swertia maerosperma C.B.Clark for the first time.

关 键 词：大籽獐牙菜 酮 研究 

分 类 号：R282.5[医药卫生—中药学]