棉酚与磺胺衍生物的合成  

Synthesis of Sulfanilamide and Gossypol's Derivatives

作　　者：祝世发[1] 唐辉[1] 赵文斌[1] 

机构地区：[1]新疆石河子大学药学院,石河子832002

出　　处：《北方药学》2011年第1期60-61,共2页Journal of North Pharmacy

摘　　要：目的:本文考察了棉酚与磺胺的衍生物合成工艺的条件,及合成物的抗菌活性,反应条件涉及温度、物料比、反应时间及反应溶剂等各条件对反应收率的影响。方法:通过正交设计寻找最佳工艺,运用熔点测定仪、元素分析、IR和1HNMR进行确认。通过薄层色谱法监测反应进行程度。结果:棉酚与磺胺衍生物合成的最佳工艺为反应温度50℃,反应时间为3h,反应溶剂为无水乙醇,物料比为1∶2.5。结论:生成的衍生物有较强的脂溶性,在优化工艺下进行反应产量较高,为棉酚与磺胺的衍生物合成提供了较好的方法。Objective：In this paper, a method of studying sulfanilamide and gossypol＇s derivatives synthesis technology of conditions, and composition＇s antibacterial activity, reaction conditions concerned with reaction temperation, ratio of reactants, reaction time and sort of solvent.Methods： by orthogonal experimental design search for best process,use melting point apparatus ,UV,IR,NMR determination measure whether have the new material.By TLC monitor the extent of reactions. Result：sulfanilamide and gossypol＇s derivatives synthesis teehnology of best condition is reaction temperation 50℃, reaction time 3h, sort of solvent is anhydrous , and alcohol ratio of reactants 1：2.5. Antibacterial experiment no obvious effect..Conelusion： these derivatives have strong fat-soluble, by orthogonal experimental design search for best process have high yield, and provide a good method of studying sulfanilamide and gossypol＇s derivatives synthesis.

关 键 词：棉酚 磺胺 合成 抗菌活性 

分 类 号：R284.2[医药卫生—中药学]