刺五加水煎煮提取动力学模型的建立  

Kinetic model for extraction of Acanthopanax Senticosus

作　　者：韩林辛[1] 倪键[1] 玄律[2] 窦津晶[1] 

机构地区：[1]北京中医药大学中药学院,北京100102 [2]北京市海淀区北太平庄医院,北京100088

出　　处：《中成药》2011年第2期240-245,共6页Chinese Traditional Patent Medicine

基　　金：十一五国家科技支撑计划课题(2006BAI09B07)

摘　　要：目的:以Fick’s第一定律为基础,建立中药刺五加水煎煮提取的动力学模型。方法:讨论中药刺五加水煎煮提取过程中药材颗粒粒度(σ1)、溶剂倍量(M)和提取时间(t)与刺五加药材有效成分浸出量之间的关系。以高效液相色谱法测定刺五加水煎煮刺五加苷B和E含量,将测定结果代入数学模型进行拟合。结果:刺五加水煎煮提取有效成分的自然对数随时间、溶剂倍量的自然对数变化成良好线性关系,最终建立溶质、浓度(CB)模型R为刺五加充分吸收水分与干质量之比。结论:本公式符合工业生产实际,但温度条件仍需进一步研究。AIM：To establish kinetic model for extraction of Acanthopanax Senticosus based on Fick’s first law.METHODS： Extraction time（t）,particle size（σ1） and solvent load（M） were considered as parameters in extraction of Acanthopanax senticosus.HPLC was used to determine the contents of eleutherosi de B and E as mark-ers.RESULTS： The relation of natural logarithm of active components of Acanthopanax Senticosus to extraction time,and solvent load was of approximate linearity,and solute concentration（CB） model was expressed as R stood for the proportion of dry weight of Acanthopanax senticosus to the full wet.CONCLUSION： The model is fitted with the industrial practice,but the condition for temperature deserves further study.

关 键 词：刺五加 动力学模型 提取 

分 类 号：R284.2[医药卫生—中药学]