离心造粒法制备托拉塞米缓释小丸胶囊及其释放度考察  

Studies on Preparation of Torasemide Sustained-Release Pellets Capsules by Centrifugal Granulator and Release Behavior in vitro

作　　者：谢燕萍[1] 

机构地区：[1]佛山市第一人民医院,广东佛山528000

出　　处：《中国药师》2011年第3期391-394,共4页China Pharmacist

摘　　要：目的:制备托拉塞米缓释小丸胶囊。方法:采用离心造粒粉末层积法制备托拉塞米小丸,用丙烯酸树脂水分散体包衣,并对包衣小丸的释药特征进行探讨。结果:微晶纤维素(MCC)空白母核32～40目的收率约80.2%,含药素丸20～24目收率约87.6%,使用Eudragit NE30D包衣液,包衣增重10%。托拉塞米缓释胶囊体外释药行为较好地符合Higuchi方程。结论:在优化的工艺条件下可制得表面光滑、圆整度高的托拉塞米缓释小丸。Objective： To prepare torasemide sustained-release pellets capsules. Method： Torasemide sustained-release pellets capsules were prepared by powder layering technique in a centrifugal granulation equipment and coated with Eudragit NE30D. The release mechanism was also studied in vitro. Result： The yield of core pellets prepared with MCC was 80. 2% （32-40 mesh） ,and the yield of drug pellets was 87. 6% （20-24 mesh）. The coating fluid was Eudragit NE30D with coating weight gain of 10%. The preparation had good sustained release behaviour accorded to Higuchi equation. Conclusion： Under the optimal preparation conditions, torasemide sustained-release pellets have perfect shape and surface characteristics.

关 键 词：托拉塞米 缓释小丸 离心造粒法 体外释放度 

分 类 号：R944.9[医药卫生—药剂学]