PNS患者急性期反应蛋白与ICI及肾功能之间关系的研究  

Correlation of acute phase proteins with ICI and renal function in patients with primary nephrotic syndrome

作　　者：林书典[1] 詹锋[1] 黄云[1] 潘楚瑛[1] 李文宁[1] 

机构地区：[1]海南省人民医院肾病内科,海南海口570311

出　　处：《中国热带医学》2011年第4期481-482,共2页China Tropical Medicine

摘　　要：目的探讨原发性肾病综合征（Pfimary nephrotie syndrome，PNS）患者急性期蛋白与肾小球内凝血指数（Itraglomerular coagulationindex，ICI）及肾功能之间的关系，以期为防治PNS肾功能衰竭提供新的策略。方法收集我院2007年1月～2009年12月期间住院治疗的PNS患者56例，所有入选病例均为初发未经治疗的PNS患者。按ICI高低分组。ICI〈0．5为L组（26例），ICI〉1．0为H组（30例）。检测尿中24h尿蛋白定量（Upro）和尿显微蛋白降解产物（FDP），用以计算ICI（ICI=Upm／FDP）；检测血中C-反应蛋白（CRP）、纤维蛋白原（FIB）、C3、血清肌酐（Scr）、铁蛋白（Fe）、白介素-6（IL-6），按按Cockcroft—Gault公式计算内生肌酐清除率（Ccr），比较两组间以上指标差异，并对相关指标进行pearson分析。结果H组中CRP、FIB、C3、Scr、IL-6和Ccr均显著高于L组，差异具有统计学意义（P〈0．05），而Fe在两组间差异无统计学意义（P〉0．05）。相关分析表明，CPR、FIB、IL-6均分别与ICI、Scr和Ccr呈正相关关系（尸〈0．05）；Fe与ICI呈正相关（P〈0．05），而与Scr和Ccr无明显相关关系（黔0．05）。结论PNS患者体内急性期蛋白CRP、FIB和IL-6水平。可做为反映肾小球内凝血状态和肾小球滤过率变化的参考指标之一。Aim To investigate the correlation of acute phase proteins with intraglomerular coagulation index （ICI） and renal function in patients with primary nephrotie syndrome （PNS） and to provide a new strategy for treatment of PNS. Methods There 56 patients,definitely diagnosis as PNS firstly,were divided into two groups according to the ICI （ICI= Upro/TDP）,those whose ICI less than 0.5 wee assigned to low ICI group （L group,26 patients ）; the other,ICI over 1 ,were assigned to high ICI group （H group, 30 patients）. The 2d-hour urine of all the cases were collected and the urinary protein （Upro）,FDP; the levels of C-reactive protein （CRP）,fibrinogen （FIB）,C3,serum creatinine （Scr）,ferritin （Fe） and interleukin -6 （IL-6） in blood were measured,and the creatinine clearance rate （Cer） was calculated according to the Cockcroft-Gauh formula. Results The levels of CRP,FIB,C3,Scr,IL-6 and Ccr in H geoup were significandy higher than that of the L group,showing statistically significant differences（P〈0.05）,and the serum Fe level between the two groups showed no significant difference （P〉0.05）. The levels of CPR,FIB,IL-6 were positively correlated with that of ICI,Scr and Ccr,respectively （P〈0.05）; the levels of Fe and ICI were positively correlated （P〈0.05）,while the level of Fe was not correlated with that of Ser and Ccr （P〉0.05）. Conclusion The levels of CRP,FIB,and IL-6 at acute phase can be taken as the important reference index in analyzing the coagulation status in glomeruli and glomerular filtration rate in patients with PNS.

关 键 词：肾病综合征 急性期蛋白 高凝状态 肾功能 

分 类 号：R692[医药卫生—泌尿科学]