Synthesis and Antimicrobial Activity of 2-Methyl-5-nitroaniline Derivatives： A Structure-Activity Relationship Study  

作　　者：Lingappa, Mallesha Kikkeri, N. Mohana Devaraju, Rakshith Sreedharamurthy, Satish 

机构地区：[1]Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570006, India [2]Department of Studies in Microbiology, University of Mysore, Manasagangotri, Mysore 570006, India

出　　处：《Chinese Journal of Chemistry》2011年第1期102-108,共7页中国化学（英文版）

摘　　要：A series of 2-methyl-5-nitroaniline derivatives, 5a--Sk and 6a--6f, were synthesized in order to determine their in vitro antimicrobial activity. The chemical structures of the synthesized compounds were confirmed by elemental analyses, UV-visible, FT-IR, 1H NMR and 13C NMR spectral studies. The structure-activity relationships of the synthesized compounds were also discussed. Among the synthesized compounds, 5f, 5d, 6b and 6e showed good antimicrobial activity compared to standard drugs.A series of 2-methyl-5-nitroaniline derivatives, 5a--Sk and 6a--6f, were synthesized in order to determine their in vitro antimicrobial activity. The chemical structures of the synthesized compounds were confirmed by elemental analyses, UV-visible, FT-IR, 1H NMR and 13C NMR spectral studies. The structure-activity relationships of the synthesized compounds were also discussed. Among the synthesized compounds, 5f, 5d, 6b and 6e showed good antimicrobial activity compared to standard drugs.

关 键 词：2-methyl-5-nitroaniline ALDEHYDES KETONES antimicrobials 

分 类 号：TQ455.021[化学工程—农药化工] S859.796[农业科学—临床兽医学]