An Efficient Synthesis of 3-Alkyl-2-alkyliminooxazolidin-4-one via a Domino Reaction  

作　　者：Liu Yongwei Li Zhengning Jiang Lan Zheng Aijun 

机构地区：[1]College of Environmental and Chemical Engineering, Dalian University, Dalian, Liaoning 116622, China [2]Liaoning Key Laboratory of Bioorganic Chemistry, Dalian University, Dalian, Liaoning 116622, China

出　　处：《Chinese Journal of Chemistry》2011年第2期303-308,共6页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China （No. 20672016）.

摘　　要：3-Alkyl-2-alkyliminooxazolidin-4-ones were prepared from a copper-catalyzed domino intermolecular nucleophilic addition of a-hydroxy-（or mecapto） carboxylic acid ester to carbodiimide and a followed nucleophilic substitution of the formed amino group to carboxylic acid ester. The reactions could be performed under convenient conditions and good yields were achieved in most cases.3-Alkyl-2-alkyliminooxazolidin-4-ones were prepared from a copper-catalyzed domino intermolecular nucleophilic addition of a-hydroxy-（or mecapto） carboxylic acid ester to carbodiimide and a followed nucleophilic substitution of the formed amino group to carboxylic acid ester. The reactions could be performed under convenient conditions and good yields were achieved in most cases.

关 键 词：iminooxazolidin-4-one synthesis CARBODIIMIDE a-hydroxycarboxylate 

分 类 号：TQ252.4[化学工程—有机化工] O626.13[理学—有机化学]