Spectrophotometric Determination of Albendazole Drug in Tablets： Spectroscopic Characterization of the Chargetransfer Solid Complexes  

作　　者：Refat Moamen S Mohamed Gehad G. Fathi Ahmed 

机构地区：[1]Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt [2]Department of Chemistry, Faculty of Science, Taif University, 888 Taif, Kingdom Saudi Arabia [3]Chemistry Department, Faculty of Science, Cairo University, Egypt

出　　处：《Chinese Journal of Chemistry》2011年第2期324-332,共9页中国化学（英文版）

摘　　要：Simple, rapid and reliable method for the determination of albendazole （ABZ） was described. This includes the utility of some π-acceptors such as 2,3-dichloro-5,6-dicyano-p-benzoquinone （DDQ） and 3,6-dichloro-2,5-dihydroxy-p-benzoquinone （p-CLA） for estimation of ABZ drug （act as donor）. The experimental conditions were optimized and the system obeys Beer＇s law for 7.50-80 and 10.00-85.00 ug·mL-1 of ABZ using DDQ and p-CLA, respectively. The molar absorptivity and Sandell sensitivity were calculated to be 1.83× 10^3 and 1.12× 10^3 L·mol ·cm -1 and 2.60 and 3.40 ng·cm -2 using DDQ and p-CLA, respectively. The limits of detection and quantification were calculated to be （7.42 and 6.73） and （9.94 and 4.13） ug·mL-1 using DDQ and p-CLA, respectively. The proposed methods were successfully applied to the determination of ABZ in commercially available dosage forms. The reliability of the assays was established by parallel determination by the official method and recovery studies. The chemical structures of the solid charge-transfer （CT） complexes formed via reaction between ABZ under study and π-acceptors, have been elucidated using elemental analyses （C, H and N）, IR, 1H NMR and mass spectra.Simple, rapid and reliable method for the determination of albendazole （ABZ） was described. This includes the utility of some π-acceptors such as 2,3-dichloro-5,6-dicyano-p-benzoquinone （DDQ） and 3,6-dichloro-2,5-dihydroxy-p-benzoquinone （p-CLA） for estimation of ABZ drug （act as donor）. The experimental conditions were optimized and the system obeys Beer＇s law for 7.50-80 and 10.00-85.00 ug·mL-1 of ABZ using DDQ and p-CLA, respectively. The molar absorptivity and Sandell sensitivity were calculated to be 1.83× 10^3 and 1.12× 10^3 L·mol ·cm -1 and 2.60 and 3.40 ng·cm -2 using DDQ and p-CLA, respectively. The limits of detection and quantification were calculated to be （7.42 and 6.73） and （9.94 and 4.13） ug·mL-1 using DDQ and p-CLA, respectively. The proposed methods were successfully applied to the determination of ABZ in commercially available dosage forms. The reliability of the assays was established by parallel determination by the official method and recovery studies. The chemical structures of the solid charge-transfer （CT） complexes formed via reaction between ABZ under study and π-acceptors, have been elucidated using elemental analyses （C, H and N）, IR, 1H NMR and mass spectra.

关 键 词：ALBENDAZOLE DDQ p-CLA SPECTROPHOTOMETRY charge-transfer complexes 

分 类 号：O614.33[理学—无机化学] TQ153.2[理学—化学]