血红素氧化酶-1基因启动子区(GT)n重复序列多态性与潮汕人群2型糖尿病易感性间的关联研究  

Association Study of (GT)n Polymorphism in Heme Oxygenase-1 Gene Promoter and Susceptibility of Type 2 Diabetes Mellitus in Chaoshan Population

作　　者：张国红[1] 麦瑞琴[2] 陈宋明[2] 

机构地区：[1]汕头大学医学院病理学教研室 [2]汕头大学医学院第一附属医院心血管内科,广东汕头515041

出　　处：《汕头大学医学院学报》2011年第1期3-4,37,共3页Journal of Shantou University Medical College

基　　金：广东省自然科学基金资助项目(07008215)

摘　　要：目的:探讨HO-1基因启动子区(GT)n重复序列多态性与潮汕人群2型糖尿病(T2DM)易感性间的关联。方法:采用荧光标记PCR以及毛细管电泳相结合技术检测97例糖尿病患者以及156例正常对照个体HO-1基因启动子区(GT)n重复序列多态性及其频率分布差异。重复次数n≤25,为S型等位基因,n>25为L型等位基因。结果:等位基因、基因型频率在病例与对照组中分布差异无统计学意义。在显性遗传模型下,SL+LL与SS基因型比(OR=0.8,95CI:0.5-1.4),以及隐性模型,LL与SL+SS基因型比(OR=0.8,95CI:0.5-1.5),未发现增加个体2型糖尿病发病风险的基因型。结论:HO-1基因启动子区(GT)n重复序列多态性与潮汕人群T2DM易感性无关。Objective： To assess the association between the length of（GT）n repeats in the HO-1 gene promoter and the susceptibility for type 2 diabetes mellitus（T2DM）in Chaoshan population.Methods： Ninety-seven patients with T2DM and 156 control subjects were collected.The amplification and labeling of PCR products for capillary electrophoresis were performed to genotype.（GT）n repeat polymorphism was classified into short（S,n≤25）and long（L,n 25）alleles.Results： Allelic and genotypic frequency did not differ significantly between T2DM patients and control subject.Under the dominant（SL＋LL/SS,OR=0.5,95CI：0.5-1.4）and recessive（LL/SL＋SS,OR=0.5,95CI：0.5-1.4）genetic model,the risk genotype was not obtained.Conclusion： Longer（GT）n repeat allele in HO-1 promoter is not associated with the susceptibility for T2DM in Chaoshan population.

关 键 词：2型糖尿病 血红素氧化酶-1 启动子区 易感性 

分 类 号：R587.1[医药卫生—内分泌]