新生儿重症监护病房医院感染败血症病原菌及耐药性研究  

Antibiotic resistance of pathogens causing hospital-acquired septicemia in neonatal intensive care unit

作　　者：钟巧[1] 杨传忠[1] 高晓玲[1] 段纯[1] 李志玲[1] 李晖[1] 

机构地区：[1]南方医科大学附属深圳市妇幼保健院医院感染管理科,广东深圳518028

出　　处：《中华医院感染学杂志》2011年第7期1456-1458,共3页Chinese Journal of Nosocomiology

摘　　要：目的研究新生儿重症监护病房医院感染败血症病原学及耐药性特征,为临床合理使用抗菌药物提供依据。方法从2006年1月-2009年12月在新生儿重症监护病房共监测确诊医院感染败血症54例,分析研究病原菌学及耐药性特征。结果病原菌分布主要革兰阳性球菌25株,占46.3%,革兰阴性杆菌16株,占29.6%,真菌13株,占24.1%;各年度病原菌谱的改变:革兰阳性球菌的比率在逐年下降,革兰阴性杆菌是逐年上升;葡萄球菌属存在较严重的耐药现象,未发现耐万古霉素耐药菌株;革兰阴性杆菌存在多药耐药现象,鲍氏不动杆菌多药耐药性更为突出。结论近年来NICU医院感染败血症的病原菌谱已发生改变,革兰阴性杆菌在逐年上升;医院感染败血症的病原菌耐药率高,对常用的抗菌药物普遍耐药,加强病原菌特别是多药耐药菌监测,可为临床合理使用抗菌药物提供依据。OBJECTIVE To study the characteristics of the pathogens and antibiotic resistance on hospital-acquired septicemia in NICU to provide a basis for reasonable clinical administration of antibiotics.METHODS The clinical data of all the 54 cases of hospital-acquired septicemia were monitored and diagnosed in NICU in the four years from Jan 2006 to Dec 2009 and the characteristics of the pathogens and antibiotic resistance were analyzed.RESULTS 25 strains of Gram-positive bacteria accounted for 46.3%,16 cases of Gram-negative bacteria accounted for 29.6%,13 cases of fungi accounted for 24.1%;Spectrum change yearly： The ratio of G＋ cocci decreased year by year,G-bacteria was increased year by year.Resistance of Staphylococcus was severe,but no vancomycin resistant strain was found.Gram-negative bacilli existed multi-drug resistant,multi-drug resistance of Acinetobacter baumannii was more prominent.CONCLUSION Pathogens of NICU nosocomial septicemia in recent years have changed,G-bacilli is increasing.Antibiotic resistance rate of hospital sepsis is high,and generally resistant to commonly used antibiotics.Strengthening the monitoring of pathogens,especially multidrug resistant pathogens,can provide the clinical basis for the reasonable use of antibiotics.

关 键 词：新生儿重症监护病房 医院感染 病原菌 耐药性 

分 类 号：R378[医药卫生—病原生物学]