紫锥菊、黄芪对法氏囊病雏鸡的肝损伤及脾脏NK细胞活性的影响  

Effect of Echinacea-Astragalus on liver damage and NK cytoactive in spleen of chickens infected with IBDV

作　　者：倪耀娣[1,2] 乔健[1] 徐建忠[3] 刘荣欣[2] 

机构地区：[1]中国农业大学动物医学院,北京100193 [2]河北农业大学中兽医学院,河北定州073000 [3]河北农业大学动物科技学院,河北保定071000

出　　处：《中国兽医学报》2011年第4期561-564,共4页Chinese Journal of Veterinary Science

基　　金：河北省科技攻关计划项目(07220401D)

摘　　要：给14日龄雏鸡灌服不同浓度紫锥菊、黄芪合剂,连续灌服7d,21日龄时雏鸡接种传染性法氏囊病病毒(IB-DV),来观察雏鸡血液转氨酶活性及脾脏NK细胞活性的变化。结果显示,攻毒后4d和攻毒后11d时用药组与攻毒对照组相比,谷草转氨酶(Ast)、谷丙转氨酶(Alt)均有所降低,差异显著(P<0.05);攻毒后11d时Ast/Alt比值极显著低于攻毒对照组(P<0.01)。脾脏NK细胞活性在感染后14d,高剂量组活性极显著高于攻毒对照组和空白对照组(P<0.01),感染21d后各组差异不显著。结果表明,紫锥菊、黄芪合剂在雏鸡感染IBDV后12d前后一段时间可显著降低传染性法氏囊病病毒对肝脏造成的损伤,促进脾脏NK细胞的活性,增强机体的防御功能,有利于该疾病的防治。The present study was undertaken to investigate the influence of Echinacea-Astragalus mixture on liver damage and anti-virus in chickens infected with IBDV artificially.Fourteen-day-old chickens were administrated with Echinacea-Astragalus mixture at different concentrations for 7 days.Then,the chickens were innoculated with IBDV on 21 d,and changes of transaminase activity in blood and NK cytoactive in spleen were measured.The results showed that Ast and Alt in treated groups decreased to some extent,and showed significant difference compared with model group（P0.05） on 4 and 11 d postinfection.The ratio of Ast/Alt was lower than blank control group on 11 d postinfection（P0.01）.NK cytoactive in high-dose group was higher than blank control group and model group significantly on 14 d postinfection,but there existsed no significante difference on 21 d.The results revealed that Echinacea-Astragalus mixture can alleviate the liver damage induced by IBDV,promote NK cytoactive and defense function effectively on about 12 d after chickens infected with IBDV,which is profitable to prevent and cure IBD.

关 键 词：紫锥菊 IBD 肝损伤 NK细胞 

分 类 号：S852.3[农业科学—基础兽医学] S853[农业科学—兽医学]