小儿噬血细胞综合征临床特点及预后危险因素分析  

Analysis of clinical features and prognosis risk factors for hemophagocytic syndrome in children

作　　者：石杨[1] 王丽杰[2] 

机构地区：[1]中国医科大学附属第一医院新生儿科,辽宁沈阳110003 [2]中国医科大学盛京医院儿科,辽宁沈阳110004

出　　处：《中国现代医学杂志》2011年第5期645-648,651,共5页China Journal of Modern Medicine

摘　　要：目的分析小儿噬血细胞综合征(HPS)的临床特点及影响其预后的临床危险因素。方法回顾性分析2007年1月～2010年12月住院治疗的32例HPS患儿的临床症状、体征和实验室检查特点,采用Logistic回归分析方法,分析影响患儿预后的临床危险因素。结果从性别、年龄、热程、病原学、外周血白细胞计数、血小板计数、血红蛋白、乳酸脱氢酶、谷丙转氨酶、单纯天冬氨酸转移酶、三酰甘油、纤维蛋白原、C-反应蛋白、活化部分凝血活酶时间中筛选出血小板降低(OR=2.078,P<0.05)和EB病毒感染(OR=2.662,P<0.05)为HPS死亡的高危因素。结论 EB病毒感染和血小板明显降低是儿童噬血细胞综合征预后不良的高危因素。该病预后凶险,死亡率高,应早期积极治疗,降低死亡率。【Objective】 To analyze the clinical features and the clinical risk factors of prognosis in child hemophagocytic syndrome（HPS）.【Methods】 A retrospective study was carried out to analyze the clinical and laboratory data of 32 HPS children from January,2007 to December,2010.Then Logistic regression was used to identify the clinical risk factors for prognosis to HPS.【Results】 From gender,age,duration of fever,etiology,peripheral blood leukocyte count,platelet count,hemoglobin,lactate dehydrogenase,alanine aminotransferase,aspartate aminotransferase,triglyceride,fibrinogen,C-reactive protein,activated partial thromboplastin time,we selected that platelet count（OR =2.078,P 0.05） and EB virus infection（OR =2.662,P 0.05） are the risk factors for death to HPS.【Conclusions】 EB virus infection and significantly reduced platelet are two risk factors for poor prognosis to HPS.It＇s an extremely dangerous state with high mortality,early aggressive treatment should be carried out to reduce the mortality rate.

关 键 词：噬血细胞综合征 预后 EB病毒感染 血小板 

分 类 号：R725[医药卫生—儿科]