当归多糖铁复合物在大鼠体内2种不同吸收途径的研究  

The research of Angelica sinensis polysaccharide-iron complex absorbed from two different pathway in normal rats

作　　者：刘茂昌[1] 张玉[2] 王凯平[1] 刘金玉[1] 李石军[2] 曾芳[1] 

机构地区：[1]华中科技大学同济医学院药学院,湖北武汉430030 [2]华中科技大学同济医学院协和医院药剂科,湖北武汉430022

出　　处：《中国医院药学杂志》2011年第7期531-535,共5页Chinese Journal of Hospital Pharmacy

基　　金：湖北省自然基金重点项目(编号:2008CDA064)

摘　　要：目的:通过当归多糖铁复合物(APIC)2种不同方式给药来探讨其在大鼠体内以游离铁离子形式吸收与直接以多糖铁复合物分子形式吸收这2种不同吸收途径。方法:分别进行正常大鼠APIC高、中、低剂量组灌胃给药和十二指肠给药实验。以原子吸收法测定各时间点血清铁浓度,用DAS2.0软件求算药动学参数。结果:APIC在大鼠体内的药动学过程均符合二室模型,且在本实验所采用剂量范围AUC随着剂量的增加也相应增大。同等剂量灌胃给药,不加抗坏血酸组AUC比加抗坏血酸组AUC稍大。且APIC能以多糖铁复合物分子形式被十二指肠吸收。结论:APIC既能以游离铁离子形式又能以多糖铁复合物分子形式被十二指肠吸收。OBJECTIVE To investigate the two different pathway of Angelica sinensis polysaccharide-iron complex（APIC） absorbed in the form of ferri ion or directly in the form of polysacebaride iron molecule in normal rats with two different administration ways. METHODS Normal rats were assigned into three groups, APIC low, medium, and high dosage groups, serum iron concentration were assayed by atomic absorption spectrometry after ig administration and id administration of APIC respectively, the pharmacokinetics parameters were analyzed by DAS 2.0 program. RESULTS The concentration time curves of APIC in rats were fitted to two compartment model and the AUC increased accordingly as the accretion of the dosage in the dos age range chosen in this experiment. The AUC of the group with no Vitamin C was larger than that of the group with Vitamin C of the same APIC dosage after ig administration. And APIC can be absorbed in the form of polysaccharide-iron molecule at duodenum. CONCLUSION APIC can be absorbed not only in the form of ferri ion but also in the form of polysaccharide-iron molecule at duodenum.

关 键 词：当归多糖铁复合物 灌胃给药 十二指肠给药 药动学 

分 类 号：R285.6[医药卫生—中药学]