参芎化瘀胶囊镇痛和镇静作用及急性毒性试验  

Study on the of analgesic and sedative effects and acute toxicity induced by Shenxiong Huayu capsule

作　　者：张爱国[1] 张博男[2] 齐亚娟[2] 李建民[3] 

机构地区：[1]华北煤炭医学院附属医院药剂科,河北唐山063000 [2]华北煤炭医学院药理教研室,河北唐山063000 [3]华北煤炭医学院附属医院神经外科,河北唐山063000

出　　处：《中国医院药学杂志》2011年第7期570-572,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的:观察参芎化瘀胶囊(SXHYC)的镇静催眠和镇痛作用及急性毒性。方法:通过小鼠扭体法和小鼠热板法观察镇痛作用;并采用戊巴比妥钠阈下剂量致小鼠睡眠法,观察药物的镇静催眠作用;通过检测小鼠的最大耐受剂量,考察SXHYC的急性毒性。结果:SXHYC能抑制醋酸致小鼠扭体反应,提高小鼠热板法痛阈值。另外,SXHYC能提高戊巴比妥钠阈下剂量小鼠睡眠率。小鼠对SXHYC一日最大耐受剂量相当于成人临床用量的384倍。结论:SXHYC具有明显的镇痛和镇静作用,且急性用药安全。OBJECTIVE To observe the analgesic and sedative effects and acute toxicity of Shen Xiong Hua Yu capsule （SXHYC） in mice. METHODS The analgesic effect was tested by the hot-plate and torsivesive malposition in mice. The drug＇s sedative effect was developed by using subthreshold dose of sleeping induced by sodium pentobarbital. The maximum tolerated dose in mice was observed so as to study the acute toxicity of SXHYC. RESULTS SXHYC could inhibit writhing response induced by acetic acid and enhance hot plate pain threshold in mice. In addition, SXHYC enhanced the sleeping rate in mice affected by subthreshold dosage of pentobarbital sodium. The maximum tolerated dose of SXHYC in mice is equivalent to 384 times the clinical dose for adults. CONCLUSION SXHYC has obvious analgesic and sedative effects, and it is safe when acute use.

关 键 词：参芎化瘀胶囊 镇痛作用 镇静作用 急性毒性 

分 类 号：R285.6[医药卫生—中药学]