乌司他丁联合大黄治疗急性胰腺炎大鼠的实验研究  

Experimental study on combined use of Ulinastatin and Rhubarb in treatment of acute pancreatitis in rats

作　　者：周智宏[1] 张国顺[1] 徐厚君[2] 田国华[1] 

机构地区：[1]华北煤炭医学院附属医院消化内科,河北唐山063000 [2]华北煤炭医学院预防医学系,河北唐山063000

出　　处：《中国生化药物杂志》2011年第2期131-133,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探讨乌司他丁(UTI)、生大黄联合应用对急性胰腺炎(AP)模型大鼠的氧自由基、血清淀粉酶及肿瘤坏死因子α(TNF-α)等的影响。方法 60只雄性SD大鼠随机分为4组:假手术组、AP组、UTI组和UTI联合大黄组,每组15只。除假手术组外,其余各组均建立AP模型,分别于手术及治疗后12 h测定各实验组大鼠血清淀粉酶、TNF-α、SOD和MDA的变化。结果 UTI组、UTI联合大黄组与AP组相比,其血清淀粉酶、TNF-α及MDA下降,胰腺湿/干重比和血清SOD水平则明显升高。UTI联合大黄组较UTI组的各指标变化趋势更为显著(P<0.01)。结论 UTI和大黄联合治疗可有效治疗大鼠AP,效果优于单独使用UTI。Purpose To investigate the effects of Ulinastatin in combination with Rhubarb on oxygen radical,amylase（AMS） and tumor-necrosis-factors（TNF-α） in rats with acute pancreatitis（AP）.Methods 60 SD rats were radomly divided into four groups：Sham-operation group（Ⅰ）,AP group（Ⅱ）,Ulinastatin-treated group（Ⅲ） and Ulinastatin combined with Rhubarb-treated group（Ⅳ）.Each group has 15 rats.AP model was made except for Sham-operation group.After operation and treament for 12 hours,the serum SOD,MDA,AMS and TNFα were observed.Results Compared with the AP group,the amylase,TNF-α and MDA of Ⅲ and Ⅳ group were more lower.The SOD and W/D were increased,moreover,each target of Ⅳ group changed more remarkably than that of Ⅲ group.Conclusion Ulinastatin combined with Rhubarb has a therapeutic effect on AP of rats and is more effective than either of them.

关 键 词：乌司他丁 生大黄 急性胰腺炎 

分 类 号：R285[医药卫生—中药学]