肝舒胶囊的成型工艺研究  

Research on formulation technique of Ganshu Capsule

作　　者：梅建宏 

机构地区：[1]常州方圆制药有限公司,江苏常州213022

出　　处：《中国生化药物杂志》2011年第2期143-144,共2页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探讨肝舒胶囊的成型条件。方法从粉末和颗粒的吸湿性、流动性等几个方面进行考察。结果采用3%羧甲基淀粉钠为辅料所制颗粒的临界相对湿度约为61%,休止角为29.68°,堆密度为0.65 g/mL,可选用0号胶囊进行装量。结论本成型工艺可行,利于制粒,制成的颗粒流动性好,利于填充。Purpose To investigate the formulation technique of Ganshu Capsule.Methods Investigateing the hygroscopicity,flowability,etc of the powder and granule.Results The zero angle was 29.68°,the bulk density was 0.65 g/mL,the critical relative humidity was 50%,and the 3% CMS was chosen as the adjuvant.The type of capsule was defined as 0#.Conclusion The pharmaceutical technique chosen is superior in particle fluency and in granulation.

关 键 词：肝舒胶囊 成型工艺 

分 类 号：R944.5[医药卫生—药剂学]