慢性阻塞性肺疾病患者血清TNF-a和IL-8的检测及临床意义  

Chronic obstructive pulmonary disease patients with TNF-a and IL-8 and clinical significance of determination

作　　者：李国芬[1] 

机构地区：[1]河南省南阳市中心医院检验中心,473000

出　　处：《中国现代药物应用》2011年第4期21-22,共2页Chinese Journal of Modern Drug Application

摘　　要：目的探讨肿瘤坏死因子-a(TNF-a)和白细胞介素-8(IL-8)在慢性阻塞性肺疾病(COPD)发病机制中的作用。方法收集33例急性加重期、32例缓解期COPD患者和18名健康者的血清,采用酶联免疫吸附法测定血清中IL-8和TNF-a。结果 COPD急性加重期组IL-8(62.1±19.3)、TNF-a(37.5±10.9)和缓解期组血清IL-8(25.2±8.4)、TNF-a(27.3±7.7)水平明显高于对照组IL-8(7.80±2.15)、TNF-a(21.6±8.9),差异有统计学意义(P<0.05),且COPD急性加重期TNF-a、IL-8又明显高于缓解期,差异有统计学意义(P<0.05)。结论 TNF-a和IL-8共同参与了COPD气道炎症反应与COPD的发病有关。Objective To investigate the role of tumor necrosis factor-a（TNF-a） and interleukin-8（IL-8） in chronic obstructive pulmonary disease（COPD） in the pathogenesis.Methods 33 patients with acute exacerbation,32 patients in remission in patients with COPD and 18 healthy blood serum by enzyme linked immunosorbent assay of serum IL-8 and TNF-a.Results Of acute exacerbation of COPD group IL-8（62.1 ± 19.3）,TNF-a（37.5 ± 10.9） and remission serum IL-8（25.2 ± 8.4）,TNF-a（27.3 ± 7.7） was significantly higher than controlgroup of IL-8（7.80 ± 2.15）,TNF-a（21.6 ± 8.9）,the difference was statistically significant（P0.05）,and COPD with acute exacerbation of TNF-a,IL-8 also significantly higher than that of remission,There was a significant difference（P0.05）.Conclusion TNF-a and IL-8 to participate in the COPD airway inflammation and the pathogenesis of COPD.

关 键 词：慢性阻塞性肺疾病 白细胞介素-8 肿瘤坏死因子-A 

分 类 号：R563.9[医药卫生—呼吸系统]