冠心病合并抑郁患者的血管内皮功能的临床研究  

Clinical Study on Endothelial Function of Patients with Coronary Heart Disease Accompanied by Depression

作　　者：黄宇玲[1] 谢芳[2] 张薇薇[1] 朱小茼[3] 

机构地区：[1]中国河北联合大学附属医院心内科,唐山063000 [2]河北联合大学附属医院超声科 [3]河北联合大学心理学院

出　　处：《中国健康心理学杂志》2011年第3期281-283,共3页China Journal of Health Psychology

基　　金：唐山市科技局卫生临床技术研究项目(课题编号:10150204A-30)

摘　　要：目的探讨冠心病合并抑郁患者的血管内皮功能及临床意义。方法 320例经冠脉造影确诊的冠心病患者根据汉密顿抑郁量表(HAMD)评定,抑郁组192例和非抑郁组128例,所有入选者均接受肱动脉超声检查和血清一氧化氮(NO)、内皮素(ET)浓度测定。结果抑郁组与非抑郁组的冠心病患者FMD%、NMD%、NO、ET比较差别有统计学意义(P<0.05),抑郁组与非抑郁组的冠心病患者冠状动脉Gensini评分比较差别有统计学意义(χ2=5.31,P<0.05),抑郁组与非抑郁组的冠心病患者病情稳定与不稳定的比例比较差别有统计学意义(χ2=19.3,P<0.001)。结论抑郁组的冠心病患者比非抑郁组的冠心病患者血管内皮功能的受损程度严重,冠脉病变狭窄程度严重,病情趋于不稳定。Objective To explore endothelial function of the patients with coronary heart disease accompanied by depression and clinical significance.Methods A total of 320 patients with coronary heart disease diagnosed by coronary artery angiography were divided into two group according to the results of Hamilton Rating Scale for Depression（HAMD）,one group（n=192） for depression,another group（n=128） for without depression.All patients had been examined by ultrasonic detection of brachial artery.In addition,the levels of nitric oxide（NO） and endothelins（ET） were measured.Results There was significant difference between the depression group and the without depression group in terms of FMD%,NMD%,NO and ET（P〈0.05）.There was significant difference in the score of Gensini between the depression group and the without depression group（χ2=5.31,P〈0.05）.The ratio of unstable / stable angina in the patients with depression group was significant higher than that of coronary heart disease without depression（χ2=19.3,P〈0.001）.Conclusion The impairment of endothelial function and the severity of coronary atherosclerosis are more severe in the patients with depression than those in the patients without depression.The condition of the patients in depression group tends to unstable.

关 键 词：抑郁 冠心病 内皮功能 超声 

分 类 号：R541.4[医药卫生—心血管疾病]