旺拉格-37味丸对亚急性衰老小鼠自主活动记忆力、游泳耐力、SOD的影响  

The Effects of Wanglage-37pill on the Autonomous Activity、Memory Swimming Endurance and SOD of Subacute Aging Mice

作　　者：布仁巴图[1] 韩志强[1] 巴图德力根[1] 高玉峰[1] 青玉[1] 

机构地区：[1]内蒙古民族大学附属医院,内蒙古通辽028007

出　　处：《中华中医药学刊》2011年第4期700-702,共3页Chinese Archives of Traditional Chinese Medicine

摘　　要：目的:观察旺拉格-37对D-半乳糖所致小鼠亚急性衰老模型的自主活动、记忆能力、游泳耐力及SOD活性的影响,验证其强身、抗衰老作用。方法:将小鼠按体重随即分为空白对照组、模型组、旺拉格-37、抗衰复春片组。旺拉格-37组以3g/kg、抗衰复春片组0.7g/kg、均0.2mL/10g灌胃给药,模型组与对照组灌胃同体积的蒸馏水,每日1次,连续灌胃45天。给药的同时模型组和给药组小鼠每天颈背部皮下注射5%D-半乳糖,0.5mL/只,连续注射49天。空白对照组皮下注射等量的生理盐水。观察旺拉格-37对D-半乳糖所致亚急性衰老小鼠自主活动、跳台学习记忆能力及学习记忆遗忘、游泳时间和血清SOD活性的影响。结果:旺拉格-37可使D-半乳糖所致亚急性衰老小鼠的站立次数和活动次数明显增多,与模型组比较有显著性差异P<0.05;明显增强学习记忆和延长学习记忆遗忘时间,可使跳台实验潜伏期延长,错误次数减少,与模型组比较P<0.05;明显延长衰老小鼠游泳时间,与模型组比较P<0.05;升高血清SOD活性,与模型组比较P<0.05。结论旺拉格-37能够改善D-半乳糖所致亚急性衰老小鼠的多项体征,具有强壮身体、抗疲劳、抗衰老作用。Objective：To observe the effects of Wanglage-37pill on the Autonomous activity、 memory、swimming endurance and SOD of D-GlaN induced Subacute aging mice model,to validate its physical and anti-aging effects.Methods：The mice were randomly divided into control group、model group、Wanglage-37pill group and Kangshuaifuchuanpian group,Wanglage-37pill group and Kangshuaifuchuanpian group are given intragastric administration 0.2mL/10g（3g/kg） and 0.2mL/10g（0.7g/kg）,Starch control group and model group are given With the same volume distilled water intragastric administration 0.2mL/10g once a day,continue to have 45days.Administration at the same time,model group are given 5%D-GlaN Neck back hypodermic each rat 0.5mL once a day,continue to have 49days,Starch control group are given Subcutaneous With the same volume distilled water.To observe the effects of Wanglage-37pill on the Autonomous activity、 memory、swimming endurance and SOD of D-GlaN induced Subacute aging mice model.Results： Wanglage-37pill group obviously increased the stand number and the number of activities of D-GlaN induced Subacute aging mice,compared with model group have significant differences P﹤0.05;Significantly enhanced and extended the time of learning memory and forgetting;to extend the step down test latency and reduce the number of errors,compared with model group P﹤0.05;Significantly extended the swimming time of subacute aging mice,compared with model group P﹤0.05;to elevate the serum SOD activity,compared with model group P﹤0.05;Conclusion：Wanglage-37pill can improve a number of signs of D-GlaN induced Subacute aging mice and has a strong body、anti-fatigue、anti-aging effect.

关 键 词：旺拉格-37 衰老模型 抗疲劳 抗衰老 

分 类 号：R285[医药卫生—中药学]