IL-23/Th17轴在变应性哮喘中的研究进展  

Recent progress of IL-23/Th17 axis in allergic asthma

作　　者：杨影[1] 罗英[1] 李春林[1] 杨春平[1] 罗璝[1] 付明福[2] 廖新根[2] 

机构地区：[1]南昌大学第二附属医院耳鼻咽喉-头颈外科,南昌330006 [2]南昌大学第二附属医院骨科,南昌330006

出　　处：《生命科学》2011年第3期286-290,共5页Chinese Bulletin of Life Sciences

摘　　要：变应性哮喘是一种由辅助性T细胞(T helper cell,Th cell)调节的慢性炎症性疾病。Th1/Th2的失衡一直被认为是变应性哮喘的发病机制,Th2细胞及其分泌的细胞因子白介素4(interleukin 4,IL-4)、IL-5以及IL-13在变应性哮喘特异性症状的发病中发挥重要作用。最近研究发现Th17细胞及其分泌的IL-17参与变应性哮喘的发展过程,IL-23在Th17细胞维持生存和功能成熟中发挥重要作用,并参与抗原诱导的气道炎症反应。该文对目前IL-23/Th17轴在变应性气道炎症反应中的研究进展作一综述。Allergic asthma is a chronic inflammatory disease regulated by the T helper（Th） cells.The Th1/Th2 imbalance has been well documented in the pathogenesis of allergic asthma,Th2 cells and their cytokines such as interleukin 4（IL-4）,IL-5,and IL-13 orchestrate these pathognomonic features of asthma.Recently,Th17 cells and IL-17 have been found to participate in the development of allergic asthma,IL-23,which is essential for survival and functional maturation of Th17 cells,is involved in antigen-induced airway inflammation.In this review,current understanding of the roles of IL-23/Th17 axis in allergic airway inflammation will be summarized.

关 键 词：IL-23 TH17 IL-17 哮喘 

分 类 号：R562.25[医药卫生—呼吸系统] R362[医药卫生—内科学]