老年COPD患者呼吸困难加重时BNP测定及其意义  

Measurement and significance of brain natriuretic peptide(BNP) in elderly dyspnea patients with chronic obstructive pulmonary disease

作　　者：王胜[1] 任薇[1] 朱春冬[1] 李春颖[1] 方东革[1] 张琳[1] 季红燕[1] 

机构地区：[1]安徽中医学院第一附属医院老年呼吸科,合肥230031

出　　处：《安徽医学》2011年第3期274-276,共3页Anhui Medical Journal

摘　　要：目的探讨脑钠肽(BNP)测定在老年慢性阻塞性肺病(COPD)患者呼吸困难加重时的鉴别诊断价值。方法老年COPD呼吸困难加重患者60例,分组:合并心功能不全组20例(A组)、伴有肺动脉高压组20例(B组)及单纯COPD组20例(C组),测定并比较3组间的血浆BNP值。结果 A组、B组及C组BNP水平分别为(758.2±336.9)pg/ml、(167.9±78.6)pg/ml、(35.4±22.9)pg/ml。各组间比较,差异均有统计学意义。结论血浆BNP浓度测定对鉴别老年AECOPD患者是否伴有肺动脉高压及合并心功能不全有一定的临床应用价值。Objective To explore the clinical application value of BNP in elderly dyspnea patients with AECOPD.Methods 60 AECOPD patients were divided into 3 groups： Group A contained 20 patients combined with heart insufficiency;Group B contained 20 patients combined with pulmonary arterial hypertension（PAH）;and Group C contained 20 patients who did not have PAH or heart insufficiency.Plasma BNP levels were measured and compared among 3 groups.Results Plasma BNP levels were significantly different among 3 groups：（758.2±336.9）pg/ml in Group A,（167.9±78.6）pg/ml in Group B,and（35.4±22.9）pg/ml in Group C.Conclusion The measurement of plasma BNP levels in elderly dyspnea patients with AECOPD can be used to identify whether they are combined with PAH or heart insufficiency or not.

关 键 词：慢性阻塞性肺疾病 脑钠肽 肺动脉高压 心功能不全 

分 类 号：R563.9[医药卫生—呼吸系统]