副流感病毒3型感染肺炎患儿细胞免疫功能分析  

Analysis of immune function in children with pneumonia of PIV3 infection

作　　者：赵显虹[1] 刘继贤[1] 李瑞[1] 贾文燕[1] 

机构地区：[1]苏州大学附属儿童医院呼吸科,江苏苏州215003

出　　处：《临床肺科杂志》2011年第5期706-708,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的分析副流感病毒3型感染肺炎患儿外周血T淋巴细胞亚群、B淋巴细胞及NK细胞的变化。方法对入院儿童行痰病原学检测7种常见病毒抗原,明确病原学诊断,并用流式细胞仪检测副流感病毒3型感染患儿外周血T淋巴细胞亚群、B淋巴细胞及NK细胞值。结果副流感病毒3型肺炎患儿外周血CD16+CD56+T细胞百分率较对照组减少,CD3+T细胞百分率、CD4+T细胞百分率、CD8+T细胞百分率、CD19+CD21+B细胞百分率和对照组相仿,CD4+/CD8+比值较对照组升高。结论副流感病毒3型感染肺炎患儿细胞免疫功能紊乱。Objective To analyze the changes of T lymphocyte subsets, B lymphocyte and NK cells in pneumonia children infected by parainfluenza virus types 3 （ PIV3 ）. Methods Multl-pathogen detection using direct fluorescence antibody test （DFA） , clear etiology di- agnosis. T lymphocyte subsets, B lymphocyte and NK cells in peripheral blood in part of patients were examined by flow cytometry. Results In ,There was no significant difference in CD3 ＋ T,CD4 ＋ T,CD8＋ T cells and CD19 ＋ B cells between the patients with PIV3 pneumonia and the controls. But the ratio of NK cells were lower in group PtV3 than those in the controls （ P 〈 0.05 ）. In contrast, the ratio of CD4 ^-/CD8 ＋ increase in group PIV3 than those in the controls （ P 〈 0. 05 ）. Conclusion Parainfluenza virus types 3 （ PIV3 ） cases of pneumonia children cellular immune disorders.

关 键 词：副流感病毒3型 T淋巴细胞亚群 B淋巴细胞 NK细胞 

分 类 号：R725.6[医药卫生—儿科]