194例住院结核病人的耐药分析  

An analysis of drug resistance of acid-fast bacilli in 194 tuberculosis patients

作　　者：蔡智群[1] 林兆原[1] 彭德虎[1] 吴碧彤[1] 冯永忠[1] 

机构地区：[1]广州市胸科医院八内科,广东广州510095

出　　处：《临床肺科杂志》2011年第5期713-714,共2页Journal of Clinical Pulmonary Medicine

摘　　要：目的对194例住院结核病患者的痰标本获得的结核杆菌做耐药性检测,为临床制定抗痨方案提供一定的参考依据。方法对2007年至2010年的194例患者痰培养结核菌阳性患者的痰标本,分别做抗结核一线药物:异烟肼(INH),利福平(RFP,),乙胺丁醇(EMB),链霉素(SM)的药敏试验,了解各药在初治和复治患者中的耐药情况。结果 118例初治患者和76例复治患者对INH的耐药例数分别15和39例,耐药率分别15.25%和51.31%;对RFP的耐药例数分别10和29例,耐药率分别8.47%和38.16%;对EMB的耐药例数分别8和20例,耐药率分别6.78%和26.32%;对SM的耐药例数分别6和28例,耐药率分别5.08%和36.84%。结论初治和复治患者均对INH的耐药率最高,其次为RFP及EMB,SM。复治患者的耐药率明显增高。耐两种或以上结核药的例数明显高于初治患者。Objective To investigate the drug resistance of acid-fast bacilli to chemo-drugs for tubereuolosis patients. Methods acid-fast bacilli were isolated from 194 patients with tuberculosis. The resistance to isoniazid （INH） , rifampicin （RFP,） , ethambutol （EMB）, streptomycin （SM） were detected. Results The resistance rate of patients of newly diagnosed and recurred is 15.25%, 51.31% to INH, 8.47%, 38.16% to REP, 6.78%, 26.32% to EMB and 5.08%, 36.84% to streptomysin respectively, drug resist- ance is much more common in relapsed patients. Conclusion Drug resistance to INH is much common than REP, EMB and SM both in tuberculosis patients. In recnred patients the resistance rate become higher and muhy-resistance is more common.

关 键 词：结核 初治和复治 耐药 

分 类 号：R446.5[医药卫生—诊断学]