门诊抗结核治疗致白细胞降低130例分析及对策  

The analysis and strategy for the decrease of white blood cell in 130 outpatients with anti-Tuberculosis treatment

作　　者：刘文[1] 杨金边[1] 刘米佳 陈靖赜 陈兆辉[1] 

机构地区：[1]武汉市医疗救治中心,湖北武汉430023 [2]武汉市中心血站,湖北武汉430032

出　　处：《临床肺科杂志》2011年第5期724-726,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨门诊结核病人标准抗结核方案导致病人白细胞（WBC）降低发生率、类型、原因、对策及预后。方法回顾我院门诊2009年1～3月2283例已接受标准抗结核方案治疗出现WBC降低的患者130例进行分析。结果WBC总数降低130例，发生率为5．7％；中性粒细胞降低64例；酸性粒细胞降低25例；同时下降为41例。白细胞降低出现时间多为1～2月。维持抗结核的同时加强升自治疗而完成疗程129例，中断治疗1例。结论出现WBC降低发生率较高（5．7％），类型呈多样化，原因多种，门诊抗结核病药物治疗虽有风险，但及时发现和处理得当，门诊抗结核病药物对结核病治疗效果及安全性是肯定的。Objective The aim of the study is to explore the incidence of WBC decreaseduring standard anti-TB therapeutic pro- grams, as well as the prevention strategy and prognosis. Method The data of 130 cases with WBC decrease out of 2283 outpatients whohave been treated with anti-TB therapeutic programs from January to March of 2009 were analyzed. Result The decrease of WBC was de- tected in 130 cases out of 2283 patients, the rate was 5.7% ;64 patients showed lower neutrophil; 25 cases were diagnosed as eosinophilic granulopenia; 41 cases with the decrease of the both neutrophil and eosinophilic granuloeytes. Most of the patients completed the standard anti-TB treatment, 129 cases were treated with WBC enhance therapy, and the 1 case failed. Conclusion The high incidence of WBC decrease was found （5.7%） in anti-TB treatment. Out-patient treatment risks the side effects of anti-tuberculosis drugs, but, if diagnosed and treated properly, the standard anti-TB program is still a safe and effective therapy.

关 键 词：门诊 抗结核药物 白细胞降低 

分 类 号：R595.3[医药卫生—内科学]