贯黄感冒颗粒抗甲型流感病毒的作用  

Antiviral effect of Guanhuang Ganmao Granule on influenza virus A

作　　者：贾翎[1] 张志远[2] 曾郁敏[1] 吴珺[1] 顾立刚[1] 吴莹[1] 邱泽计[1] 祈广见[1] 葛东宇[1] 

机构地区：[1]北京中医药大学中医药防治病毒性疾病教育部重点实验室,北京100029 [2]海南医学院药学院,海口571101

出　　处：《中华中医药杂志》2011年第4期663-666,共4页China Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：目的:观察贯黄感冒颗粒体内、外抗甲型流感病毒的作用。方法:体外观察贯黄感冒颗粒对甲型流感病毒H1N1和H3N2致细胞病变作用的影响,体内观察其对甲型流感病毒FM1感染小鼠的保护作用。结果:贯黄感冒颗粒体外对所试两株病毒所致的细胞病变均显示抑制作用,对H1N1的IC50为1.38mg/mL,TI为5.66;对H3N2的IC50为0.69mg/mL,TI为11.31。体内实验结果显示贯黄感冒颗粒中剂量组可降低甲型流感病毒FM1感染所致小鼠的死亡率,延长平均生存时间。结论:贯黄感冒颗粒体内外均有抗甲型流感病毒的作用。Objective：To observe the antiviral effect of Guanhuang Ganmao Granule on influenza virus A in vitro and in vivo experiments.Methods：Observed the cytopathic effect of Guanhuang Ganmao Granule on influenza virus A HIN1 and H3N2 in vitro,observed its protective effect on the mice infected with influenza virus FM1.Results：Guanhuang Ganmao Granule can inhibit the cell pathological effect caused by influenza virus A in vitro;to H1N1,its IC50 is 1.38 mg/mL,TI is 5.66;to H3N2,its IC50 is 0.69 mg/mL,TI is 11.31.In the medium-dose Guanhuang Ganmao Granule can reduce the mortality of the mice infected with FM1 strain of influenza virus A,prolong the average survival time.Conclusion：Guanhuang Ganmao Granule shows antiviral effect in vitro and in vivo.

关 键 词：贯黄感冒颗粒 流感病毒 抗病毒 体内 体外 

分 类 号：R285[医药卫生—中药学]