针刺调整超前性光暗周期转移后节律紊乱的时相特征研究  

Research on phase characteristic of acupuncture on circadian rhythm disturbance due to advanced light/dark cycle

作　　者：蔡定均[1] 魏焦禄[1] 赵纪岚[1] 谢川[1] 刘旭光[1] 朱丽[1] 周奇志[1] 

机构地区：[1]成都中医药大学时间生物学实验室,成都610075

出　　处：《中华中医药杂志》2011年第4期691-694,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金(No.30701125);四川省教育厅重大培育项目(No.09Z2009)~~

摘　　要：目的:揭示针刺调整金黄地鼠超前性光暗周期转移后节律紊乱的时相特征。方法:采用超前性光暗周期转移方法模拟慢性轮班工作复制昼夜节律紊乱模型,观察不同时间点电针"百会"、"长强"对金黄地鼠超前性光暗周期相位转移后节律再同步的影响。结果:在模拟超前性光暗周期转移后,金黄地鼠的活动均向前漂移。不同批次不同组动物的平均漂移幅度在156.14-586.00min之间。在ZT16(24:00)、ZT0(8:00)针刺,与自然恢复组比较,针刺组再同步所用天数虽小于自然恢复组,但是两者之间无统计学差异;在ZT4(12:00)、ZT8(16:00)、ZT12(4:00)3个时相点针刺有明显促进金黄地鼠自发活动节律再同步的作用,与自然恢复组比较有统计学差异(P<0.05);而在ZT20针刺后,针刺组重导引所用天数略长于自然恢复组,但两者之间无统计学差异。结论:针刺有肯定的促进节律再同步的作用;针刺导引节律再同步的作用具有依时相性。Objective：Research on the phase characteristic of acupuncture on the circadian rhythm disturbance produced by 10 days of serial 8-hour advances of light/dark cycle every 2 days.Methods：Syrian hamsters were synchronized to lighting conditions of LD14：10,and then,circadian rhythm disturbance models were produced by 10 days of serial 8-hour advances of light/dark cycle every 2 days.Comparing the effect of acupuncturing ＇Baihui（DU20）＇ and ＇Changqiang（DU1）＇ points after advanced light/dark cycle at different time.Results：After advanced light/dark cycle,the spontaneous behavior of golden hamsters shifted forward.Their average shift extent of different batches and different groups was from 156.14 to 586.00 min.When acupunctured at ZT16 and ZT0,the time of resynchronization was less than the natural recovery group,but they weren＇t different in statistics.Compared with other groups,the outstanding effective of promoting circadian rhythm resynchronization was observed in acupuncture group at ZT4,ZT8 and ZT12.While at ZT20 the time of resynchronization in the treated group was longer than that in the natural recovery group,but they weren＇t different in statistics.Conclusion：Firstly,acupuncture could promote circadian rhythm resynchronization.Secondly,the effective of acupuncture on resynchronization was circadian-dependent effects.

关 键 词：针刺 昼夜节律紊乱 再同步 轮班工作 相位 

分 类 号：R245[医药卫生—针灸推拿学]