黄芩、柴胡及其配伍提取物对柯萨奇病毒B3m感染Balb/c小鼠心肌炎治疗作用  

Therapeutic effect of Skullcap,Bupleurum chinense and compatibility extract on the mice with Coxsackievirus B3m myocarditis

作　　者：刘芳[1] 王雪峰[1] 南春红[1] 闫丽娟[1] 岳志军[1] 孟宪生[2] 

机构地区：[1]辽宁中医药大学附属医院,沈阳110032 [2]辽宁中医药大学药学院分析化学教研室,大连116600

出　　处：《中华中医药杂志》2011年第4期697-700,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金(No.30371832)~~

摘　　要：目的:探讨黄芩、柴胡及其配伍提取物对柯萨奇病毒B3m(CVB3m)感染小鼠心肌炎的治疗作用。方法:采用腹腔注射CVB3m诱导Balb/c小鼠心肌炎模型,用黄芩、柴胡及其配伍提取物对此动物模型进行治疗,观察各组小鼠给药后不同时间点的一般状态、存活率、心脏/体质量比值、心肌组织病理积分和心肌CVB3m病毒滴度情况。结果:3组药物均能不同程度改善模型小鼠的一般状态、心脏/体质量比值、存活率及心肌组织病理积分,同时降低模型小鼠的心肌组织病毒滴度;柴胡组和配伍组心肌组织病理积分明显低于黄芩组;黄芩组的病毒滴度明显低于柴胡组。结论:柴胡在减轻心肌病理损伤方面作用显著;黄芩在抑制病毒增殖作用方面作用显著;配伍组药物具有抑制病毒复制和减轻病理损伤作用。Objective：To explore the therapeutic effect of Skullcap extract（SE）,Bupleurum chinense extract（BCE） and compatibility extract（CE） on the mice with viral myocarditis.Methods：Viral myocardititis（VMC） model was induced by an intraperitoneal injection of Coxsackievirus B3m（CVB3m） in the BALB/c mouse.After the model was confirmed,the three treatment groups were administered with SE,BCE and CE separately.The general state,heart / body mass,survival rate,myocardial pathologic score and CVB3m viral titer in the myocardium in all groups were observed.Result：The general state,heart / body mass,survival rate,myocardial pathologic score of mice in the three treatment groups compared with the model control group were improved obviously.The viral titers of three treatment groups significantly decreased compared with the model group.The myocardial pathologic score in BCE and CE gruops significantly decreased compared with SE group.The viral titers of SE group were significantly lower than BCE group.Conclusion：Bupleurum chinense extrac significantly reduced myocardial pathologic damage.skullcap extrac can inhibited virus multiplication obviously.Compatibility extract can both inhibited virus multiplication and reduce cardiac pathological damage.

关 键 词：黄芩 柴胡 中药提取物 病毒性心肌炎 

分 类 号：R285.5[医药卫生—中药学]